ArticleNature neuroscience2011
The columnar and laminar organization of inhibitory connections to neocortical excitatory cells.
Article in Nature neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.
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Who cites it
147 citing papers in PubMed.
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- Blind identification of state transitions and latent neural dynamics from electrophysiological recordings.Journal of neuroscience methods · 2026Article
- Layered structure of cortex explains reversal dynamics in bistable perception.Scientific reports · 2025Article
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- Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model.bioRxiv : the preprint server for biology · 2025Article
- Enhanced beta power emerges from simulated parkinsonian primary motor cortex.NPJ Parkinson's disease · 2025Article
- Enhanced beta power emerges from simulated parkinsonian primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Neural heterogeneity enhances reliable neural information processing: Local sensitivity and globally input-slaved transient dynamics.Science advances · 2025Article
- Self-organized and self-sustained ensemble activity patterns in simulation of mouse primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Multi-coil TMS for preclinical applications in ultra-high-field MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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- Optogenetic Determination of Dynamic and Cell-Type-Specific Inhibitory Reversal Potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Agranular frontal cortical microcircuit underlying cognitive control in macaques.Frontiers in neural circuits · 2024Review
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- Generation and propagation of bursts of activity in the developing basal ganglia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- Foramen lacerum impingement of trigeminal nerve root as a rodent model for trigeminal neuralgia.JCI insight · 2023Article
- Article
87 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
The cytoarchitectonic similarities of different neocortical regions have given rise to the idea of 'canonical' connectivity between excitatory neurons of different layers within a column. It is unclear whether similarly general organizational principles also exist for inhibitory neocortical circuits. Here we delineate and compare local inhibitory-to-excitatory wiring patterns in all principal layers of primary motor (M1), somatosensory (S1) and visual (V1) cortex, using genetically targeted photostimulation in a mouse knock-in line that conditionally expresses channelrhodopsin-2 in GABAergic neurons. Inhibitory inputs to excitatory neurons derived largely from the same cortical layer within a three-column diameter. However, subsets of pyramidal cells in layers 2/3 and 5B received extensive translaminar inhibition. These neurons were prominent in V1, where they might correspond to complex cells, less numerous in barrel cortex and absent in M1. Although inhibitory connection patterns were stereotypical, the abundance of individual motifs varied between regions and cells, potentially reflecting functional specializations.
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