ArticleNature nanotechnology2010
Identifying single bases in a DNA oligomer with electron tunnelling.
Article in Nature nanotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed.
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
- Decoding information stored in DNAs through single-molecule electrical detection platforms.Innovation (Cambridge (Mass.)) · 2025Review
- Engineering Charge Transport by Tunneling in Supramolecular Assemblies through Precise Control of Metal-Ligand Interactions.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Sustainable Integration of Nanobiosensors in Biomedical and Civil Engineering: A Comprehensive Review.ACS omega · 2025Review
- Single-Molecule Bioelectronic Sensors with AI-Aided Data Analysis: Convergence and Challenges.Precision chemistry · 2024Review
- Electromigrated Gold Nanogap Tunnel Junction Arrays: Fabrication and Electrical Behavior in Liquid and Gaseous Media.ACS applied materials & interfaces · 2024Article
- Nanopore DNA sequencing technologies and their applications towards single-molecule proteomics.Nature chemistry · 2024Review
- Label-Free Imaging of DNA Interactions with 2D Materials.ACS photonics · 2024Article
- Dynamical control of nanoscale light-matter interactions in low-dimensional quantum materials.Light, science & applications · 2024Review
- Effect of surface functionalization on DNA sequencing using MXene-based nanopores.RSC advances · 2024Article
- Local cation-tuned reversible single-molecule switch in electric double layer.Nature communications · 2023Article
- Graphene-molecule-graphene single-molecule junctions to detect electronic reactions at the molecular scale.Nature protocols · 2023Review
- Advances in single-molecule junctions as tools for chemical and biochemical analysis.Nature chemistry · 2023Review
- Recent Advances in Single-Molecule Sensors Based on STM Break Junction Measurements.Biosensors · 2022Review
- Article
- Label-Free Optical Analysis of Biomolecules in Solid-State Nanopores: Toward Single-Molecule Protein Sequencing.ACS photonics · 2022Review
- Planar Boronic Graphene and Nitrogenized Graphene Heterostructure for Protein Stretch and Confinement.Biomolecules · 2021Article
- Programmable nano-reactors for stochastic sensing.Nature communications · 2021Article
- Single-molecule junction spontaneously restored by DNA zipper.Nature communications · 2021Article
- Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations.Nature communications · 2021Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
It has been proposed that single molecules of DNA could be sequenced by measuring the physical properties of the bases as they pass through a nanopore. Theoretical calculations suggest that electron tunnelling can identify bases in single-stranded DNA without enzymatic processing, and it was recently experimentally shown that tunnelling can sense individual nucleotides and nucleosides. Here, we report that tunnelling electrodes functionalized with recognition reagents can identify a single base flanked by other bases in short DNA oligomers. The residence time of a single base in a recognition junction is on the order of a second, but pulling the DNA through the junction with a force of tens of piconewtons would yield reading speeds of tens of bases per second.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.