ArticleNature structural & molecular biology2010
Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.
Article in Nature structural & molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- The molecular mechanism of fluoride export by the eukaryotic fluoride channel FEX.Nature communications · 2025Article
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- Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.Nature communications · 2023Article
- Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.Microbiology spectrum · 2021Article
- N-terminal Transmembrane-Helix Epitope Tag for X-ray Crystallography and Electron Microscopy of Small Membrane Proteins.Journal of molecular biology · 2021Article
- A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation.Nature communications · 2021Article
- Complement factor H protects tumor cell-derived exosomes from complement-dependent lysis and phagocytosis.PloS one · 2021Article
- Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans.PLoS pathogens · 2019Article
- Application of antihelix antibodies in protein structure determination.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations.Nature communications · 2019Article
- Molecular Docking and Molecular Dynamics (MD) Simulation of Human Anti-Complement Factor H (CFH) Antibody Ab42 and CFH Polypeptide.International journal of molecular sciences · 2019Article
- Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.Nature communications · 2017Article
- Metastability Gap in the Phase Diagram of Monoclonal IgG Antibody.Biophysical journal · 2017Article
- Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.Cell reports · 2016Article
- Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee.EBioMedicine · 2015Article
- Article
- Article
- Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide.Journal of virology · 2014Article
- Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66.6.Journal of virology · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation.
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