ArticleNature chemical biology2011
Cardiac glycosides are potent inhibitors of interferon-β gene expression.
Article in Nature chemical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- ATP1A1/BCL2L1 predicts the response of myelomonocytic and monocytic acute myeloid leukemia to cardiac glycosides.Leukemia · 2024Article
- Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads.Molecules (Basel, Switzerland) · 2022Review
- Anticancer and Antiviral Properties of Cardiac Glycosides: A Review to Explore the Mechanism of Actions.Molecules (Basel, Switzerland) · 2020Review
- Identification of Molecular Markers Associated With the Pathophysiology and Treatment of Lupus Nephritis Based on Integrated Transcriptome Analysis.Frontiers in genetics · 2020Article
- Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease.FASEB bioAdvances · 2019Article
- A research update on the anticancer effects of bufalin and its derivatives.Oncology letters · 2019Review
- Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice.Scientific reports · 2019Article
- Suppression of mRNA Nanoparticle Transfection in Human Fibroblasts by Selected Interferon Inhibiting Small Molecule Compounds.Biomolecules · 2017Article
- Toll-like receptor 3 activation selectively reverses HIV latency in microglial cells.Retrovirology · 2017Article
- Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy.Molecules (Basel, Switzerland) · 2016Review
- Identification of cellular microRNA-136 as a dual regulator of RIG-I-mediated innate immunity that antagonizes H5N1 IAV replication in A549 cells.Scientific reports · 2015Article
- ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells.Journal of virology · 2015Article
- Signaling function of Na,K-ATPase induced by ouabain against LPS as an inflammation model in hippocampus.Journal of neuroinflammation · 2014Article
- Intracellular calcium regulates nonsense-mediated mRNA decay.Nature medicine · 2014Article
- Toad glandular secretions and skin extractions as anti-inflammatory and anticancer agents.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Anti-inflammatory and antinociceptive activities of bufalin in rodents.Mediators of inflammation · 2014Article
- A unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses.Microbes and infection · 2013Review
- Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects.Oncoimmunology · 2012Article
- 5'-Triphosphate-short interfering RNA: potent inhibition of influenza A virus infection by gene silencing and RIG-I activation.Journal of virology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Here we report that bufalin and other cardiac glycoside inhibitors of the sodium-potassium ATPase (sodium pump) potently inhibit the induction of the interferon-β (IFNβ) gene by virus, double-stranded RNA or double-stranded DNA. Cardiac glycosides increase the intracellular sodium concentration, which appears to inhibit the ATPase activity of the RNA sensor RIG-I, an essential and early component in the IFNβ activation pathway. This, in turn, prevents the activation of the critical transcription factors IRF3 and NFκB. Bufalin inhibition can be overcome by expressing a drug-resistant variant of the sodium pump and knocking down the pump by short hairpin RNA inhibits IFNβ expression. Thus, bufalin acts exclusively through the sodium pump. We also show that bufalin inhibits tumor necrosis factor (TNF) signaling, at least in part by interfering with the nuclear translocation of NFκB. These findings suggest that bufalin could be used to treat inflammatory and autoimmune diseases in which IFN or TNF are hyperactivated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.