ArticleVirchows Archiv. A, Pathological anatomy and histopathology1990
Immunohistochemical study of the abnormal cells in Langerhans cell histiocytosis (histiocytosis x).
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 36 citations in OpenAlex.
- Langerhans Cell Histiocytosis Shows Distinct Cytoplasmic Expression of Major Histocompatibility Class II Antigens.Journal of hematopathology · 2016Article
- Neither IL-17A mRNA nor IL-17A protein are detectable in Langerhans cell histiocytosis lesions.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Expression of the monoclonal antibody HECA-452 defined E-selectin ligands in Langerhans cell histiocytosis.Virchows Archiv : an international journal of pathology · 1996Article
- Differential Expression of Markers in Extensive and Restricted Langerhans Cell Histiocytosis (LCH).Pathology oncology research : POR · 1996Article
- Langerhans' cell histiocytosis: expression of leukocyte cellular adhesion molecules suggests abnormal homing and differentiation.The American journal of pathology · 1994Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immunophenotypic properties of the abnormal cells in routine specimens from 16 cases of Langerhans cell histiocytosis (LCH) were examined. In five cases, cryostat sections were also available. The abnormal cells expressed a similar phenotype and were positive for HLA-DR, S-100 protein, peanut agglutinin (PNA), CD1a, CD4 and several macrophage-associated markers, including CD11c, CDw32 and CD68 (the latter detectable in routine sections with antibody KP1). Staining with CD14, CD35 (C3b receptor), and CD11b (C3bi receptor) was negative with the exception of one of the cases in which a proportion of the cells showed faint positivity with CD11b. Staining for pan-T-cell (CD2, CD3, CD5) and pan-B-cell (CD19, CD22) antigens was negative in all lesions. It is concluded that LCH expresses a characteristic phenotype with some heterogeneity with regard to macrophage markers and that immunohistochemical methods in cryostat sections and routine specimens form a useful supplement to other techniques for the diagnosis of this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.