Evidence map›Paper›PMID 21076181›Full record

ArticleAging2010

The telomere protein tankyrase 1 regulates DNA damage responses at telomeres.

Sandy Chang

Abstract readEditorialComment
In one paragraph

Article in Aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Controversial aspects of oncogene-induced senescence.Cell cycle (Georgetown, Tex.) · 2012
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Sandy Chang

Funding

Telomere induced senescence as a supressor of tumorigenesisR01CA129037 · NCI · YALE UNIVERSITY · PI CHANG, SANDY S · 2007 to 2017
$3.1M
NCI NIH HHS R01 CA129037
6 · The paper itself

Abstract

The proliferative potential of eukaryotic cells is critically dependent upon the maintenance of functional telomeres, the protein-DNA complexes that cap the ends of chromosomes. A paper published in this issue of Aging describes that the telomere protein tankyrase 1 regulates DNA damage responses at telomeres.

Indexed as

AnimalsCellular SenescenceDNA-Activated Protein KinaseDNA RepairHumansMiceNeoplasmsNuclear ProteinsProteasome Endopeptidase ComplexProtein Processing, Post-TranslationalSister Chromatid ExchangeTankyrasesTelomereDNA-Activated Protein KinaseNuclear ProteinsPRKDC protein, humanProteasome Endopeptidase ComplexTankyrasesTNKS protein, human

Identifiers

PMID21076181
PMCPMC2993793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.