ReviewEukaryotic cell2011
Comparative genomics and the evolution of pathogenicity in human pathogenic fungi.
Review in Eukaryotic cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 110 citations in OpenAlex.
- Interconnected worlds: a comprehensive review of fungal defenses, antimicrobial resistance, and their evolutionary dynamics.IMA fungus · 2026Review
- Genomic insights into the ecological versatility of Tetracladium spp.BMC genomics · 2025Article
- Filamentation Profiling Reveals Multiple Transcription Regulators Contributing to the Differences Between Candida albicans and Candida dubliniensis.Molecular microbiology · 2025Article
- Variations in virulence factors, antifungal susceptibility and extracellular polymeric substance compositions of cryptic and uncommon Candida species from oral candidiasis.BMC oral health · 2025Article
- From Natural Hosts to Agricultural Threats: The Evolutionary Journey of Phytopathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Ellagic Acid Potentiates the Inhibitory Effects of Fluconazole AgainstAntibiotics (Basel, Switzerland) · 2024Article
- Universal signatures of transposable element compartmentalization across eukaryotic genomes.bioRxiv : the preprint server for biology · 2024Article
- Exploring the Biology, Virulence, and General Aspects ofInfection and drug resistance · 2024Review
- Candidiasis in breast cancer: Tumor progression or not?Iranian journal of basic medical sciences · 2024Review
- Glycerophosphocholine provision rescuesmSphere · 2023Article
- Environmental reservoirs of the drug-resistant pathogenic yeast Candida auris.PLoS pathogens · 2023Review
- Article
- Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence AcrossGenetics · 2020Article
- Gut microbiome of endangered Tor putitora (Ham.) as a reservoir of antibiotic resistance genes and pathogens associated with fish health.BMC microbiology · 2020Article
- Carboxylic Acid Transporters inmBio · 2020Review
- Diversity and Complexity of the Large Surface Protein Family in the Compacted Genomes of MultiplemBio · 2020Article
- Virulence assessment of six major pathogenic Candida species in the mouse model of invasive candidiasis caused by fungal translocation.Scientific reports · 2020Article
- Genomics and Virulence ofFrontiers in genetics · 2020Article
- Antivirulence and avirulence genes in human pathogenic fungi.Virulence · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because most fungi have evolved to be free-living in the environment and because the infections they cause are usually opportunistic in nature, it is often difficult to identify specific traits that contribute to fungal pathogenesis. In recent years, there has been a surge in the number of sequenced genomes of human fungal pathogens, and comparison of these sequences has proved to be an excellent resource for exploring commonalities and differences in how these species interact with their hosts. In order to survive in the human body, fungi must be able to adapt to new nutrient sources and environmental stresses. Therefore, genes involved in carbohydrate and amino acid metabolism and transport and genes encoding secondary metabolites tend to be overrepresented in pathogenic species (e.g., Aspergillus fumigatus). However, it is clear that human commensal yeast species such as Candida albicans have also evolved a range of specific factors that facilitate direct interaction with host tissues. The evolution of virulence across the human pathogenic fungi has occurred largely through very similar mechanisms. One of the most important mechanisms is gene duplication and the expansion of gene families, particularly in subtelomeric regions. Unlike the case for prokaryotic pathogens, horizontal transfer of genes between species and other genera does not seem to have played a significant role in the evolution of fungal virulence. New sequencing technologies promise the prospect of even greater numbers of genome sequences, facilitating the sequencing of multiple genomes and transcriptomes within individual species, and will undoubtedly contribute to a deeper insight into fungal pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.