ArticleApplied and environmental microbiology2011
Extracellular aldonolactonase from Myceliophthora thermophila.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 56 citations in OpenAlex.
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- Quantitative comparison of the biomass-degrading enzyme repertoires of five filamentous fungi.Scientific reports · 2020Article
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- Methods for Expression, Purification, and Characterization of PqqE, a Radical SAM Enzyme in the PQQ Biosynthetic Pathway.Methods in enzymology · 2018Article
- Lignin degradation: microorganisms, enzymes involved, genomes analysis and evolution.FEMS microbiology reviews · 2017Review
- Myceliophthora thermophila M77 utilizes hydrolytic and oxidative mechanisms to deconstruct biomass.AMB Express · 2016Article
- PqqD is a novel peptide chaperone that forms a ternary complex with the radical S-adenosylmethionine protein PqqE in the pyrroloquinoline quinone biosynthetic pathway.The Journal of biological chemistry · 2015Article
- Dissecting structural and electronic effects in inducible nitric oxide synthase.The Biochemical journal · 2015Article
- Genomics review of holocellulose deconstruction by aspergilli.Microbiology and molecular biology reviews : MMBR · 2014Review
- Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing.The Journal of biological chemistry · 2014Article
- Analysis of thermophilic fungal populations during phase II of composting for the cultivation of Agaricus subrufescens.World journal of microbiology & biotechnology · 2014Article
- Analysis of a conserved cellulase transcriptional regulator reveals inducer-independent production of cellulolytic enzymes in Neurospora crassa.MicrobiologyOpen · 2013Article
- Efficient plant biomass degradation by thermophilic fungus Myceliophthora heterothallica.Applied and environmental microbiology · 2013Article
- Cellulose degradation by oxidative enzymes.Computational and structural biotechnology journal · 2012Review
- Heterologous expression of Pycnoporus cinnabarinus cellobiose dehydrogenase in Pichia pastoris and involvement in saccharification processes.Microbial cell factories · 2011Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Fungi secrete many different enzymes to deconstruct lignocellulosic biomass, including several families of hydrolases, oxidative enzymes, and many uncharacterized proteins. Here we describe the isolation, characterization, and primary sequence analysis of an extracellular aldonolactonase from the thermophilic fungus Myceliophthora thermophila (synonym Sporotrichum thermophile). The lactonase is a 48-kDa glycoprotein with a broad pH optimum. The enzyme catalyzes the hydrolysis of glucono-δ-lactone and cellobiono-δ-lactone with an apparent second-order rate constant, k(cat)/K(m), of ~1 × 10(6) M(-1) s(-1) at pH 5.0 and 25°C but is unable to hydrolyze xylono-γ-lactone or arabino-γ-lactone. Sequence analyses of the lactonase show that it has distant homology to cis-carboxy-muconate lactonizing enzymes (CMLE) as well as 6-phosphogluconolactonases present in some bacteria. The M. thermophila genome contains two predicted extracellular lactonase genes, and expression of both genes is induced by the presence of pure cellulose. Homologues of the M. thermophila lactonase, which are also predicted to be extracellular, are present in nearly all known cellulolytic ascomycetes.
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