Trial reportDrug and alcohol dependence2011
Assessing white matter integrity as a function of abstinence duration in former cocaine-dependent individuals.
Trial report in Drug and alcohol dependence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- A meta-analysis of tract-based spatial statistics studies examining white matter integrity in cocaine use disorder.Addiction biology · 2021Pooled it
- Regional differences in white matter integrity in stimulant use disorders: A meta-analysis of diffusion tensor imaging studies.Drug and alcohol dependence · 2019Pooled it
- Trial
- rsfMRI effects of KB220Z™ on neural pathways in reward circuitry of abstinent genotyped heroin addicts.Postgraduate medicine · 2015Trial
- Substance use and the value of control.Cognitive, affective & behavioral neuroscience · 2026Article
- Anterior and posterior cerebral white matter show different patterns of microstructural alterations in young adult smokers.Brain imaging and behavior · 2025Article
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment.Drug and alcohol dependence reports · 2024Article
- Residual deficits in functional brain activity after chronic cocaine self-administration in rhesus monkeys.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Updated Perspectives on the Neurobiology of Substance Use Disorders Using Neuroimaging.Substance abuse and rehabilitation · 2023Review
- Prefrontal-habenular microstructural impairments in human cocaine and heroin addiction.Neuron · 2022Article
- Altered white matter microstructure and neurocognitive function of HIV-infected patients with low nadir CD4.Journal of neurovirology · 2022Article
- Strengthened and posterior-shifted structural rich-club organization in people who use cocaine.Drug and alcohol dependence · 2022Article
- The impact of levamisole and alcohol on white matter microstructure in adult chronic cocaine users.Addiction biology · 2022Article
- Assessing combinatorial effects of HIV infection and former cocaine dependence on cognitive control processes: A high-density electrical mapping study of response inhibition.Neuropharmacology · 2021Article
- White matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis.Translational psychiatry · 2021Article
- Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.PloS one · 2021Article
- Neurocognitive impairment and gray matter volume reduction in HIV-infected patients.Journal of neurovirology · 2020Article
- Regional elevations in microglial activation and cerebral glucose utilization in frontal white matter tracts of rhesus monkeys following prolonged cocaine self-administration.Brain structure & function · 2019Article
- Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research.Drug and alcohol dependence · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Current cocaine-dependent users show reductions in white matter (WM) integrity, especially in cortical regions associated with cognitive control that have been associated with inhibitory dysfunction. A key question is whether these white matter differences are present following abstinence from drug use. To address this, WM integrity was examined using diffusion tensor imaging (DTI) obtained on 43 cocaine abstinent patients (abstinence duration ranged between five days and 102 weeks) and 43 non-using controls. Additionally, a cross-sectional comparison separated the patients into three groups (short-term, mid-term and long-term) based upon duration of cocaine abstinence. The 43 cocaine abstinent patients showed lower fractional anisotropy (FA) in the left anterior callosal fibers, left genu of the corpus callosum, right superior longitudinal fasciculus, right callosal fibers and the superior corona radiata bilaterally when compared against non-using controls. Higher FA in the cocaine abstinent patients was observed in the splenium of the corpus callosum and right superior longitudinal fasciculus. Differences between the cocaine abstinent groups were observed bilaterally in the inferior longitudinal fasciculus, right anterior thalamic radiation, right ventral posterolateral nucleus of the thalamus, left superior corona radiata, superior longitudinal fasciculus bilaterally, right cingulum and the WM of the right precentral gyrus. The results identified WM differences between cocaine abstinent patients and controls as well as distinct differences between abstinent subgroups. The findings suggest that specific white matter differences persist throughout abstinence while other, spatially distinct, differences discriminate as a function of abstinence duration. These differences may, therefore, represent brain changes that mark recovery from addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.