ReviewThrombosis research2011
Platelets as immune mediators: their role in host defense responses and sepsis.
Review in Thrombosis research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03090919 (The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis), which is not on this map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis
Who cites it
52 citing papers in PubMed.
- The potential of antimicrobials to induce thrombocytopenia in critically ill patients: data from a randomized controlled trial.PloS one · 2013Trial
- Factors influencing thrombocytopenia in geriatric patients in the intensive care unit: a retrospective observational study.BMC geriatrics · 2025Observational
- Hormonal and electrolyte predictors for methotrexate versus surgery in ectopic pregnancy.PloS one · 2025Article
- Platelet count has a U-shaped association with mortality in hemodialysis patients.Scientific reports · 2024Article
- Retrospective analysis of interpretable machine learning in predicting ICU thrombocytopenia in geriatric ICU patients.Scientific reports · 2024Article
- Continuation of chronic antiplatelet therapy is not associated with increased need for transfusions: a cohort study in critically ill septic patients.BMC anesthesiology · 2024Article
- Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries.Diagnostics (Basel, Switzerland) · 2024Article
- The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies.Turkish journal of obstetrics and gynecology · 2023Article
- Prediction of Acute Kidney Injury in Intracerebral Hemorrhage Patients Using Machine Learning.Neuropsychiatric disease and treatment · 2023Article
- Association of Systemic Immune Inflammation Index with All-Cause, Cardiovascular Disease, and Cancer-Related Mortality in Patients with Cardiovascular Disease: A Cross-Sectional Study.Journal of inflammation research · 2023Article
- Stable CAD patients show higher levels of platelet-borne TGF-β1 associated with a superior pro-inflammatory state than the pro-aggregatory status; Evidence highlighting the importance of platelet-derived TGF-β1 in atherosclerosis.Journal of thrombosis and thrombolysis · 2023Article
- Indications that the Antimycotic Drug Amphotericin B Enhances the Impact of Platelets on Aspergillus.Antimicrobial agents and chemotherapy · 2022Article
- Roles and mechanisms of garlic and its extracts on atherosclerosis: A review.Frontiers in pharmacology · 2022Review
- Association of the systemic immune-inflammation index with all-cause mortality in patients with arteriosclerotic cardiovascular disease.Frontiers in cardiovascular medicine · 2022Article
- The platelet-lymphocyte ratio is a promising predictor of early postoperative acute kidney injury following cardiac surgery: a case-control study.Annals of translational medicine · 2021Article
- Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3.American journal of respiratory cell and molecular biology · 2021Article
- Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats.Scientific reports · 2021Article
- Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives.International journal of molecular sciences · 2020Review
- Standardization and Validation of Fluorescence-Based Quantitative Assay to Study Human Platelet Adhesion to Extracellular-Matrix in a 384-Well Plate.International journal of molecular sciences · 2020Article
- Impaired Glucose Tolerance is Associated with Enhanced Platelet-Monocyte Aggregation in Short-Term High-Fat Diet-Fed Mice.Nutrients · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Platelets occupy a central role at the interface between thrombosis and inflammation. At sites of vascular damage, adherent platelets physically and functionally interact with circulating leukocytes. Activated platelets release soluble factors into circulation that may have local and systemic effects on blood and vascular cells. Platelets can also interact with a wide variety of microbial pathogens. Emerging evidence from animal models suggests that platelets may participate in a wide variety of processes involving tissue injury, immune responses and repair that underlie diverse diseases such as atherosclerosis, autoimmune disorders, inflammatory lung and bowel disorders, host-defense responses and sepsis. In this review, we summarize the general mechanisms by which platelets may contribute to immune function, and then discuss evidence for their role in host defense responses and sepsis from preclinical and clinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.