ArticleAtherosclerosis2011
Leptin upregulates caveolin-1 expression: implications for development of atherosclerosis.
Article in Atherosclerosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Glucolipid Metabolic Disorders andInternational journal of endocrinology · 2026Review
- The Role of Adiponectin and Leptin in Fibro-Calcific Aortic Valve Disease: A Systematic Review and Meta-Analysis.Biomedicines · 2024Review
- Multifaced roles of adipokines in endothelial cell function.Frontiers in endocrinology · 2024Review
- The interaction between rs 3,807,992 genotypes with the dietary inflammatory index on Leptin, Leptin resistance, and Galectin 3 in obese and overweight women.BMC endocrine disorders · 2022Article
- Adipokines, adiposity, and atherosclerosis.Cellular and molecular life sciences : CMLS · 2022Review
- Leptin in Atherosclerosis: Focus on Macrophages, Endothelial and Smooth Muscle Cells.International journal of molecular sciences · 2021Review
- Intermittent hypoxia regulates vasoactive molecules and alters insulin-signaling in vascular endothelial cells.Scientific reports · 2018Article
- Caveolin-1 is critical in the proliferative effect of leptin on osteoblasts through the activation of Akt.Molecular medicine reports · 2016Article
- Leptin-Induced JAK/STAT Signaling and Cancer Growth.Vaccines · 2016Review
- Pulmonary hypertension and metabolic syndrome: Possible connection, PPARγ and Caveolin-1.World journal of cardiology · 2014Review
- Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Leptin signaling in adipose tissue: role in lipid accumulation and weight gain.Circulation research · 2012Article
- The barrier within: endothelial transport of hormones.Physiology (Bethesda, Md.) · 2012Review
- Role of adipokines in atherosclerosis: interferences with cardiovascular complications in rheumatic diseases.Mediators of inflammation · 2012Review
- Leptin: the missing link between obesity and heart disease?Atherosclerosis · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the role of hyperleptinemia on caveolin-1 expression and leptin signaling.
methodsEndothelial cells are critical to atherosclerosis development; therefore we investigated hyperleptinemia in cultured vascular endothelial cells. Dose-dependent effect of leptin on caveolin-1 expression was determined by Western blot analysis. Also, the consequence of increased caveolin-1 expression on leptin signaling was investigated by adenovirus mediated caveolin-1 overexpression. The effect of increased caveolin-1 expression on leptin-dependent activation of ERK1/2 and eNOS was determined by Western blot analysis.
resultsLeptin upregulates caveolin-1 protein expression in a dose dependent manner and increased caveolin-1 expression impairs leptin signaling.
conclusionsLeptin increases caveolin-1 protein expression which impairs leptin signaling in vascular endothelial cells. Our study identifies an additional leptin mediated proatherogenic mechanism and a novel caveolin-1 dependent leptin feedback mechanism which may have implications for development of peripheral leptin resistance in the endothelium.
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Registered trials
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