ReviewProgress in molecular biology and translational science2010
Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways.
Review in Progress in molecular biology and translational science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment.Molecular cancer · 2026Review
- Mitochondrial CaCell reports · 2025Article
- Identification of key regulators in pancreatic ductal adenocarcinoma using network theoretical approach.PloS one · 2025Article
- Can Echinococcus Granulosus Infestation Prevent Pancreatic Cancer? An invivo Experimental Study.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis.Nature communications · 2023Article
- Segmentation of Pancreatic Subregions in Computed Tomography Images.Journal of imaging · 2022Article
- Pancreatic Ductal Adenocarcinoma: New Insights into the Actions of Vitamin A.Oncology research and treatment · 2022Review
- Review
- Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory.Cancer cell international · 2020Review
- Mouse-Derived Allografts: A Complementary Model to the KPC Mice on Researching Pancreatic Cancer In Vivo.Computational and structural biotechnology journal · 2019Article
- Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice.Gastroenterology · 2018Article
- Lineage dynamics of murine pancreatic development at single-cell resolution.Nature communications · 2018Article
- The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities.Expert review of anticancer therapy · 2018Review
- A network-based method for identifying prognostic gene modules in lung squamous carcinoma.Oncotarget · 2016Article
- Genetics and biology of pancreatic ductal adenocarcinoma.Genes & development · 2016Review
- Developmental genes significantly afflicted by aberrant promoter methylation and somatic mutation predict overall survival of late-stage colorectal cancer.Scientific reports · 2015Article
- Pancreatic cancer and its stroma: a conspiracy theory.World journal of gastroenterology · 2014Review
- Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth.Developmental cell · 2014Article
- Decreased RGS6 expression is associated with poor prognosis in pancreatic cancer patients.International journal of clinical and experimental pathology · 2014Article
- A starring role for stellate cells in the pancreatic cancer microenvironment.Gastroenterology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Embryonic development marks a period of peak tissue growth and morphogenesis in the mammalian lifecycle. Many of the pathways that underlie cell proliferation and movement are relatively quiescent in adult animals but become reactivated during carcinogenesis. This phenomenon has been particularly well documented in pancreatic cancer, where detailed genetic studies and a robust mouse model have permitted investigators to test the role of various developmental signals in cancer progression. In this chapter, we review current knowledge regarding the signaling pathways that act during pancreatic development and the evidence that the reactivation of developmentally important signals is critical for the pathogenesis of this treatment-refractory malignancy.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.