Evidence map›Paper›PMID 21074482›Full record

ReviewCytokine & growth factor reviews2010

IL-17 family member cytokines: regulation and function in innate immunity.

Joseph M Reynolds, Pornpimon Angkasekwinai, Chen Dong

Open access · greenAbstract readReview
In one paragraph

Review in Cytokine & growth factor reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 1 synthesis or guideline pooled it, 231 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Antioxidants (Basel, Switzerland) · 2026
    Article
  4. Article
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  6. Emerging immunologic approaches as cancer anti-angiogenic therapies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  7. Article
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  10. Article
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  16. The star target in SLE: IL-17.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  17. Review
  18. Review
  19. Article
  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Joseph M ReynoldsDepartment of Immunology and Center for Inflammation and Cancer, M.D. Anderson Cancer Center, Houston, TX 77054, USA.
Pornpimon Angkasekwinai
Chen Dong
The University of Texas MD Anderson Cancer Center · USThammasat University · TH

Funding

TSLP Signaling in Dendritic Cells - Aim 3U19AI071130 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DONG, CHEN · 2006 to 2010
$6.1M
Transcriptional regulation of inflammatory helper T Cell differentiationR01AR050772 · NIAMS · UNIVERSITY OF WASHINGTON · PI DONG, CHEN · 2003 to 2016
$4.5M
Transcriptome and epigenome analysis of helper T cell specification and plasticitRC2AR059010 · NIAMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DONG, CHEN · 2009 to 2010
$2.8M
NIAID NIH HHS U19 AI071130NIAMS NIH HHS R01 AR050772NIAMS NIH HHS RC2 AR059010
6 · The paper itself

Abstract

Recently, the IL-17 family member cytokines have become prominent subjects of investigation. IL-17 (IL-17A) is the best-described member of this family where its production has been mainly attributed to a specialized T helper subset of the adaptive immune response termed Th17. However, recent research on this and other Th17 cytokines has revealed new sources and functions of IL-17 family members in the innate immune response. This review will highlight recent advances in the field of IL-17 family member cytokines and will predominantly focus on the innate regulation and function of IL-17, IL-17F, and IL-25.

Indexed as

HelminthiasisHumansHypersensitivityImmunity, InnateInflammationInterleukin-17Killer Cells, NaturalLung DiseasesMacrophagesNatural Killer T-CellsNuclear Receptor Subfamily 1, Group F, Member 3Th17 CellsIL25 protein, humanInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3

Identifiers

PMID21074482
PMCPMC3008409
OpenAlexW2017929603

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.