ArticleAlcoholism, clinical and experimental research2011
Adolescents at risk for alcohol abuse demonstrate altered frontal lobe activation during Stroop performance.
Article in Alcoholism, clinical and experimental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Intra-individual changes in Stroop-related activations linked to cigarette abstinence in adolescent tobacco smokers: Preliminary findings.Drug and alcohol dependence · 2016Trial
- Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task.Alcoholism, clinical and experimental research · 2014Trial
- Approach bias modification in alcohol dependence: do clinical effects replicate and for whom does it work best?Developmental cognitive neuroscience · 2013Trial
- Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers.Psychiatry research. Neuroimaging · 2026Article
- Intertemporal Decision-Making, Nucleus Accumbens Activation, and Alcohol Use Trajectories in Young Adults With a Family History of Alcohol Use Disorder.Alcohol, clinical & experimental research · 2026Article
- Delay Discounting, Nucleus Accumbens Activation, and Alcohol Use Trajectories in Young Adults with a Family History of Alcohol Use Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task.Human brain mapping · 2023Article
- The Use of Magnetic Resonance Imaging Techniques in Assessing the Effects of Alcohol Consumption and Heavy Drinking on the Adolescent Brain: A Scoping Review Protocol.Brain sciences · 2021Article
- Bidirectional causality between addiction and cognitive deficits.International review of neurobiology · 2021Review
- Parental Family History of Alcohol Use Disorder and Neural Correlates of Response Inhibition in Children From the Adolescent Brain Cognitive Development (ABCD) Study.Alcoholism, clinical and experimental research · 2020Article
- A cortical-brainstem circuit predicts and governs compulsive alcohol drinking.Science (New York, N.Y.) · 2019Article
- The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence.Neuropsychology · 2019Review
- Effects of adolescent alcohol consumption on the brain and behaviour.Nature reviews. Neuroscience · 2018Review
- Working memory capacity and addiction treatment outcomes in adolescents.The American journal of drug and alcohol abuse · 2018Article
- Cortical thickness and trait empathy in patients and people at high risk for alcohol use disorders.Psychopharmacology · 2017Article
- Adolescence and Drug Use Vulnerability: Findings from Neuroimaging.Current opinion in behavioral sciences · 2017Article
- Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology.Alcoholism, clinical and experimental research · 2017Article
- Volumetric Differences in Cerebellar Lobes in Individuals from Multiplex Alcohol Dependence Families and Controls: Their Relationship to Externalizing and Internalizing Disorders and Working Memory.Cerebellum (London, England) · 2016Article
- Neurobiological signatures associated with alcohol and drug use in the human adolescent brain.Neuroscience and biobehavioral reviews · 2016Review
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Funding
Abstract
backgroundChildren and adolescents, family history positive (FH+) for alcoholism, exhibit differences in brain structure and functional activation when compared to family history negative (FH-) counterparts. Given that frontal brain regions, and associated reciprocal connections with limbic structures, undergo the most dramatic maturational changes during adolescence, the objective of this study was to compare functional brain activation during a frontally mediated test of response inhibition in 32 adolescents separated into low-risk (FH-) and high-risk (FH+) groups.
methodsFunctional magnetic resonance (fMRI) blood oxygen level-dependent data were acquired at 1.5 Tesla during performance of Stroop Color Naming, Word Reading, and Interference. Preprocessing and statistical analyses, covaried for age, were conducted in SPM99 using a search territory that included superior, middle, and inferior frontal gyri (trigone region), anterior cingulate gyrus (CG), and left and right amygdala.
resultsSignificantly greater activation in the fronto-limbic search territory was observed in FH+ relative to FH- subjects during Stroop Interference. In addition, a significant regression between brain activation and family history density was observed, with a greater density being associated with increased activation in regions including middle frontal gyrus (BA9) and CG (BA24).
conclusionsThese data demonstrate a significant influence of FH status on brain activation during the performance of a response inhibition task, perhaps reflecting a neurobiological vulnerability associated with FH status that may include reduced neuronal efficiency and/or recruitment of additional neuronal resources. These findings are important given that the adolescent developmental period is already associated with reduced inhibitory capacity, even prior to the onset of alcohol use.
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