Evidence map›Paper›PMID 21073340›Full record

ReviewAnnual review of pathology2011

Mechanisms of leukocyte transendothelial migration.

William A Muller

Abstract readReview
In one paragraph

Review in Annual review of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 342 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
342citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

342 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Early atherogenesis: In search of etiology.International journal of cardiology. Cardiovascular risk and prevention · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. CSIE: cancer subtyping via inference and ensemble.Briefings in bioinformatics · 2026
    Article
  11. The role of neutrophils in the pathogenesis of abdominal aortic aneurysms.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Prostaglandin EThe American journal of pathology · 2026
    Article
  18. Linking tumour angiogenesis and tumour immunity.Nature reviews. Immunology · 2026
    Review
  19. Review
  20. Article

282 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

William A MullerDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. wamuller@northwestern.edu

Funding

TWO NOVEL VASCULAR ADHESION MOLECULES: PECAM AND HEC-1R01HL046849 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MULLER, WILLIAM A · 1991 to 2019
$6.7M
Beyond PECAM: Mechanisms of Transendothelial MigrationR37HL064774 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MULLER, WILLIAM A · 2005 to 2014
$4.0M
NHLBI NIH HHS R01 HL046849NHLBI NIH HHS R01HL046849NHLBI NIH HHS R37 HL064774NHLBI NIH HHS R37HL064774
6 · The paper itself

Abstract

Neither the innate nor adaptive immune system "responds" unless leukocytes cross blood vessels. This process occurs through diapedesis, in which the leukocyte moves in an ameboid fashion through tightly apposed endothelial borders and, in some cases, through the endothelial cell itself. This review focuses on the active role of the endothelial cell in diapedesis. Several mechanisms play a critical role in transendothelial migration, including signals derived from clustering of apically disposed intercellular adhesion molecule 1 and vascular cell adhesion molecule 1, disruption or loosening of adherens junctions, and targeted recycling of platelet/endothelial cell adhesion molecule and other molecules from the recently described lateral border recycling compartment. Surprisingly, many of the same molecules and mechanisms that regulate paracellular migration also control transcellular migration. A hypothesis that integrates the various known mechanisms of transmigration is proposed.

Indexed as

AnimalsCell MovementEndothelium, VascularHumansInflammationLeukocytesTransendothelial and Transepithelial Migration

Identifiers

PMID21073340
PMCPMC3628537

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.