ArticleIET systems biology2010
Towards monitoring real-time cellular response using an integrated microfluidics-matrix assisted laser desorption ionisation/nanoelectrospray ionisation-ion mobility-mass spectrometry platform.
Article in IET systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- A novel, low-cost microfluidic device with an integrated filter for rapid, ultrasensitive, and high-throughput bioburden detection.Scientific reports · 2023Article
- Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses.Annual review of analytical chemistry (Palo Alto, Calif.) · 2017Review
- I-Wire Heart-on-a-Chip I: Three-dimensional cardiac tissue constructs for physiology and pharmacology.Acta biomaterialia · 2017Article
- Real-time cellular exometabolome analysis with a microfluidic-mass spectrometry platform.PloS one · 2015Article
- Structural mass spectrometry of tissue extracts to distinguish cancerous and non-cancerous breast diseases.Molecular bioSystems · 2014Article
- Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure.Experimental biology and medicine (Maywood, N.J.) · 2014Review
- Scaling and systems biology for integrating multiple organs-on-a-chip.Lab on a chip · 2013Review
- Mechanistic analysis of challenge-response experiments.Biometrics · 2013Article
- Microengineered tumor models: insights & opportunities from a physical sciences-oncology perspective.Biomedical microdevices · 2013Review
- Microfluidic systems for studying neurotransmitters and neurotransmission.Lab on a chip · 2013Review
- Biomolecular signatures of diabetic wound healing by structural mass spectrometry.Analytical chemistry · 2013Article
- Engineering challenges for instrumenting and controlling integrated organ-on-chip systems.IEEE transactions on bio-medical engineering · 2013Article
- Amino acids as metabolic substrates during cardiac ischemia.Experimental biology and medicine (Maywood, N.J.) · 2012Review
- Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery.Lab on a chip · 2012Article
- A dual-column solid phase extraction strategy for online collection and preparation of continuously flowing effluent streams for mass spectrometry.Analytical chemistry · 2012Article
- Automated refinement and inference of analytical models for metabolic networks.Physical biology · 2011Article
- Mass conservation and inference of metabolic networks from high-throughput mass spectrometry data.Journal of computational biology : a journal of computational molecular cell biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The combination of microfluidic cell trapping devices with ion mobility-mass spectrometry offers the potential for elucidating in real time the dynamic responses of small populations of cells to paracrine signals, changes in metabolite levels and delivery of drugs and toxins. Preliminary experiments examining peptides in methanol and recording the interactions of yeast and Jurkat cells with their superfusate have identified instrumental set-up and control parameters and online desalting procedures. Numerous initial experiments demonstrate and validate this new instrumental platform. Future outlooks and potential applications are addressed, specifically how this instrumentation may be used for fully automated systems biology studies of the significantly interdependent, dynamic internal workings of cellular metabolic and signalling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.