ArticleDiabetologia2011
The stress of starvation: glucocorticoid restraint of beta cell development.
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Adapting Physiology in Functional Human Islet Organogenesis.Frontiers in cell and developmental biology · 2022Article
- Clinical and Anatomopathological Evaluation of BALB/c Murine Models Infected with Isolates of Seven PathogenicPathogens (Basel, Switzerland) · 2021Article
- Sex-Dependent Changes of miRNA Levels in the Hippocampus of Adrenalectomized Rats Following Acute Corticosterone Administration.ACS chemical neuroscience · 2021Article
- Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Influence of socioeconomic events on cause-specific mortality in urban Shanghai, China, from 1974 to 2015: a population-based longitudinal study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Differential effects of prenatal stress on metabolic programming in diet-induced obese and dietary-resistant rats.American journal of physiology. Endocrinology and metabolism · 2015Article
- Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats.PloS one · 2014Article
- Mind and body: how the health of the body impacts on neuropsychiatry.Frontiers in pharmacology · 2013Review
- A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding.Disease models & mechanisms · 2012Article
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2 authors.
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Abstract
Developmental insults during gestation, such as under-nutrition, are known to restrict the number of beta cells that form in the fetal pancreas and are maintained in adulthood, leading to increased risk of type 2 diabetes. There are now substantial data indicating that glucocorticoids mediate this effect of under-nutrition on beta cell mass and that even at physiological levels they restrain fetal beta cell development in utero. There are emerging clues that this occurs downstream of endocrine commitment by neurogenin 3 but prior to terminal beta cell differentiation. Deciphering the precise mechanism will be important as it might unveil new pathways by which to manipulate beta cell mass that could be exploited as novel therapies for patients with diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.