Evidence map›Paper›PMID 21072430›Full record

ReviewNatural product reports2011

Natural products as a source of Alzheimer's drug leads.

Philip Williams, Analia Sorribas, Melanie-Jayne R Howes

Abstract readReview
In one paragraph

Review in Natural product reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Multifaceted Biological Activity of Selected FlavoneInternational journal of molecular sciences · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Journal of Cancer · 2025
    Article
  14. Anticholinesterases Traits Inbuilt inCurrent neuropharmacology · 2025
    Review
  15. Harvesting Health: Phytochemicals in Cognitive Impairment Therapy.Central nervous system agents in medicinal chemistry · 2025
    Review
  16. Review
  17. Review
  18. Marine-derived Compounds: A Powerful Platform for the Treatment of Alzheimer's Disease.Central nervous system agents in medicinal chemistry · 2024
    Review
  19. Review
  20. Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Philip WilliamsDepartment of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
Analia Sorribas
Melanie-Jayne R Howes

Funding

A Needle in a Haystack: New approaches to Alzheimer's Drug Discovery from NaturalR21AG032405 · NIA · UNIVERSITY OF HAWAII AT MANOA · PI WILLIAMS, PHILIP · 2009 to 2010
$307k
NIA NIH HHS R21 AG032405PHS HHS R21AGO32405
6 · The paper itself

Abstract

This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than 180 compounds and summarizes 400 references.

Indexed as

Biological ProductsAlzheimer DiseaseHumansMolecular StructureBiological Products

Identifiers

PMID21072430
PMCPMC4917364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.