ArticleInternational journal of women's health2010
The role of progesterone in prevention of preterm birth.
Article in International journal of women's health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Vaginal Nanoformulations for the Management of Preterm Birth.Pharmaceutics · 2022Review
- Oleic acid reduces steroidogenesis by changing the lipid type stored in lipid droplets of ovarian granulosa cells.Journal of animal science and biotechnology · 2022Article
- The Microbiome as a Key Regulator of Female Genital Tract Barrier Function.Frontiers in cellular and infection microbiology · 2021Review
- Development of a mucoinert progesterone nanosuspension for safer and more effective prevention of preterm birth.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Article
- Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility.Croatian medical journal · 2017Review
- A Kinetic Study of CD83 Reveals an Upregulation and Higher Production of sCD83 in Lymphocytes from Pregnant Mice.Frontiers in immunology · 2017Article
- Modulation of Progesterone Receptor Isoform Expression in Pregnant Human Myometrium.BioMed research international · 2017Article
- Comparative Study of Vaginal versus Intramuscular Progesterone in the Prevention of Preterm Delivery: A Randomized Clinical Trial.Electronic physician · 2015Article
- Efficacy of 17α- hydroxy progestrone on decreasing preterm labor in ART pregnancies: A randomized clinical trial.Iranian journal of reproductive medicine · 2013Article
- The role of oxidative stress in menopause.Journal of mid-life health · 2013Review
- Outcome of vaginal progesterone as a tocolytic agent: randomized clinical trial.ISRN obstetrics and gynecology · 2012Article
- 17 α-Hydroxyprogesterone caproate (Makena™): in the prevention of preterm birth.Paediatric drugs · 2011Review
- Comparison of intramuscular progesterone with oral nifedipine for treating threatened preterm labor: A randomized controlled trial.Medical journal of the Islamic Republic of IranArticle
- Antifertility activity ofIndian journal of pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preterm birth continues to provide an enormous challenge in the delivery of perinatal health care, and is associated with considerable short and long-term health consequences for surviving infants. Progesterone has a role in maintaining pregnancy, by suppression of the calcium-calmodulin-myosin light chain kinase system. Additionally, progesterone has recognized anti-inflammatory properties, raising a possible link between inflammatory processes, alterations in progesterone receptor expression and the onset of preterm labor. Systematic reviews of randomized controlled trials evaluating the use of intramuscular and vaginal progesterone in women considered to be at increased risk of preterm birth have been published, with primary outcomes of perinatal death, preterm birth <34 weeks, and neurodevelopmental handicap in childhood. Eleven randomized controlled trials were included in the systematic review, involving 2714 women and 3452 infants, with results presented according to the reason women were considered to be at increased risk of preterm birth. While there is a potential beneficial effect in the use of progesterone for some women considered to be at increased risk of preterm birth, primarily in the reduction in the risk of preterm birth before 34 weeks gestation, it remains unclear if the observed prolongation of pregnancy translates into improved health outcomes for the infant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.