ArticleInternational journal of clinical and experimental medicine2010
Differential fatty acid profile in adipose and non-adipose tissues in obese mice.
Article in International journal of clinical and experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- Hepatic FGF21: Its Emerging Role in Inter-Organ Crosstalk and Cancers.International journal of biological sciences · 2022Review
- Stearidonic-Enriched Soybean Oil Modulates Obesity, Glucose Metabolism, and Fatty Acid Profiles Independently of Akkermansia muciniphila.Molecular nutrition & food research · 2020Article
- Analysis of fatty acids in mouse tissue via in situ transmethylation with biochar.Environmental geochemistry and health · 2019Article
- The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity.Cell metabolism · 2017Review
- Obesity but not high-fat diet impairs lymphatic function.International journal of obesity (2005) · 2016Article
- Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy.Analytical chemistry · 2016Article
- Aliphatic chain length by isotropic mixing (ALCHIM): determining composition of complex lipid samples by ¹H NMR spectroscopy.Journal of biomolecular NMR · 2014Article
- The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice.BMC genomics · 2013Article
- Up-regulation of stearoyl-CoA desaturase 1 increases liver MUFA content in obese Zucker but not Goto-Kakizaki rats.Lipids · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Obesity is a metabolic disease characterized by chronic inflammation. Early studies indicated that adipose tissue from obese mice contains more saturated fatty acids and that the saturated fatty acids activate TLR4-mediated inflammatory signaling, which contributes to inflammation in adipose tissue. In this study, we determined fatty acid profile in non-adipose tissues from obese (db/db) mice and compared with that from lean mice. Unexpectedly, in contrast to a significant increase in saturated and decrease in unsaturated fatty acid in adipose tissue from obese mice, the non-adipose tissues from obese mice exhibited a significant decrease in saturated and increase in unsaturated fatty acid compared with that from lean mice. The liver from obese mice had a 15% and 32% decrease in palmitic acid and stearic acid, and a 20% increase in linoleic acid; the spleen had a 32% and 60% decrease in palmitic acid and stearic acid, and a 70% and 50% increase in oleic acid and linoleic acid; and the pancreas had a 50% and 75% decrease in palmitic acid and stearic acid, and a 130% and 113% increase in oleic acid and linoleic acid. These data suggest that, different from adipose tissue where elevated saturated fatty acids contributes to inflammation, fatty acids per se in non-adipose tissues such as liver, spleen and pancreas may not contribute to inflammatory responses in obese mice.
Indexed as
Identifiers
21072264PMC2971542W1587052671What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.