ArticleInternational journal of clinical and experimental medicine2010
Characterization of a necrotizing enterocolitis model in newborn mice.
Article in International journal of clinical and experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial.The Journal of pediatrics · 2019Trial
- Inhibition of IP6K1 suppresses NPA formation via platelet short-chain polyphosphate polymers in necrotizing enterocolitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Multi-strain Probiotics for Treatment of Necrotizing Enterocolitis in Preterm Rats: Histological and Immunohistochemical Evaluation.Probiotics and antimicrobial proteins · 2026Article
- A digestive cartridge reduces intestinal injury in a murine model of necrotizing enterocolitis.PloS one · 2026Article
- Recombinant IGF-1/BP3 protects against intestinal injury in a neonatal mouse NEC model.Pediatric research · 2024Article
- Article
- Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury.EMBO reports · 2023Article
- Article
- State-of-the-art review and update ofFrontiers in pediatrics · 2023Review
- Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular development.Communications biology · 2022Article
- Maltodextrin-induced intestinal injury in a neonatal mouse model.Disease models & mechanisms · 2020Article
- A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions.Nature communications · 2019Article
- Prenatal inflammation impairs intestinal microvascular development through a TNF-dependent mechanism and predisposes newborn mice to necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Necrotizing enterocolitis attenuates developmental heart rate variability increases in newborn rats.Neurogastroenterology and motility · 2019Article
- Blocking NF-κB Activation in Ly6cThe American journal of pathology · 2019Article
- Animal models of necrotizing enterocolitis: review of the literature and state of the art.Innovative surgical sciences · 2018Review
- Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation.Nature medicine · 2018Article
- Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: role of VEGF signaling.Pediatric research · 2018Article
- Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation.The Journal of clinical investigation · 2017Article
- RNA-Seq for Gene Expression Profiling of Human Necrotizing Enterocolitis: a Pilot Study.Journal of Korean medical science · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundNecrotizingenterocolitis (NEC) is a major health concern for premature infants and its patho-genesis remains poorly understood. The current mouse NEC model has not well been characterized.
objectivesIn this study, we develop a simple mouse model of NEC and determine the role of several factors modulating human NEC (i.e., breast milk, birth weight, cesarean section and bacteria) on intestinal injury.
methodsIn a first experiment, pups born naturally and dam fed for <12 hours were gavaged with adult commensal bacteria or E. Fecalis, and exposed to hypoxia-cold stress-formula feeding, and compared with controls without bacteria inoculation. 72-hour mortality was recorded, and small intestines were examined histologically. In a second experiment, we compared the incidence of NEC in mice dam fed for <12 hours to those dam fed for 12 to 24 hours or delivered by cesarean section prior to being submitted to the NEC protocol.
resultsIn pups inoculated with 10(7) CFU of a standardized preparation of adult commensal bacteria or 10(5) CFU of E. Fecalis, the incidence of severe NEC (>grade 2) was 70% and 37% respectively vs 6% in the controls (no bacteria)(p<0.05). In pups dam fed for 12 to 24 hours, NEC incidence was 44(±12)% lower vs those dam fed less than 12 hours (p<0.05). We did not find any difference in the NEC incidence between naturally-born pups dam fed for less than 12 hours and these born by cesarean section. The incidence of severe NEC was higher in pups with low birth weight.
conclusionswe have simplified and characterized a neonatal mouse NEC model that shares several risk factors with human NEC. Now that transgenic mice are available, this model will be useful to study the role played by specific proteins in vivo in NEC development.
Indexed as
Identifiers
21072263PMC2971546What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.