ReviewKidney & blood pressure research2011
High-salt diet and hypertension: focus on the renin-angiotensin system.
Review in Kidney & blood pressure research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04894344 (Education to Decrease in Sodium Intake in University Students Evaluated With 24 Hour Urinary Sodium Excretion), which is not on this map. Cited by 90 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Education to Decrease in Sodium Intake in University Students Evaluated With 24 Hour Urinary Sodium Excretion: Randomized Controlled Trial
Who cites it
90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Exploring the benefits and safety of combining nebivolol and valsartan for managing hypertension: a systematic review.BMC cardiovascular disorders · 2026Pooled it
- Sodium-to-potassium ratio and blood pressure, hypertension, and related factors.Advances in nutrition (Bethesda, Md.) · 2014Pooled it
- The role of cyclo-oxygenase-1 in high-salt diet-induced microvascular dysfunction in humans.The Journal of physiology · 2015Trial
- The Hidden Burden of Water-Binding Additives in Meat Products: Biochemical, Clinical, and Psychosocial Implications.Molecular nutrition & food research · 2026Review
- Subclinical primary aldosteronism and major adverse cardiovascular events: evidence for a continuum of renin-independent aldosterone excess and a proposal for early detection.Frontiers in cardiovascular medicine · 2026Review
- Renin and 1-year mortality in critically ill patients with ARDS: trajectories, discrimination, and survival analysis.Frontiers in medicine · 2026Article
- Effect of Dietary Salt Excess on DNA Methylation and Transcriptional Regulation of Human Angiotensinogen Gene Expression.American journal of hypertension · 2026Article
- Anti-Obesity and Diuretic Effects of Immature Watermelon Rind Extract in HFD-Induced Obese Mice.Nutrients · 2025Article
- Pathogenic Role of mTOR Signaling in Cardiometabolic Disease: Implications for Heart, Liver, and Kidney Dysfunction.Physiological research · 2025Review
- Influence of Perceived Dietary Saltiness on Sudden Cardiac Arrest Incidence in Individuals with and without Diabetes Mellitus: A Case-Control Study.Yonsei medical journal · 2025Article
- Review
- The association between urine-estimated salt intake and hypertension: findings of a population-based study.Clinical hypertension · 2025Article
- Risk factors for diabetic retinopathy in young and middle-aged patients: a retrospective study.BMC ophthalmology · 2024Article
- Practical use and target value of urine sodium-to-potassium ratio in assessment of hypertension risk for Japanese: Consensus Statement by the Japanese Society of Hypertension Working Group on Urine Sodium-to-Potassium Ratio.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Canagliflozin attenuates kidney injury, gut-derived toxins, and gut microbiota imbalance in high-salt diet-fed Dahl salt-sensitive rats.Renal failure · 2024Article
- Article
- Review
- Transcriptome Study of 2 Black Cohorts RevealsJournal of the American Heart Association · 2024Article
- A traditional Korean fermented food,Heliyon · 2024Article
- The Mineralocorticoid Receptor in the Vasculature: Friend or Foe?Annual review of physiology · 2024Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
A high-salt diet is one of the major risk factors in the development and maintenance of hypertension. Numerous experimental and observational studies have confirmed the association of sodium intake with blood pressure levels. The effects of a high-salt diet are related to the function of the renin-angiotensin system, which is normally suppressed by a high-salt diet. Endothelial dysfunction probably plays an important role in the influence of high sodium intake on blood pressure, although the exact mechanisms remain elusive. Genetic factors are known to be very important, and various consomic and congenic rat strains as animal models have proven to be very useful in bringing us a step closer to understanding the interaction between salt intake and hypertension. In this article, experimental data obtained in studies on animals and humans, as well as epidemiological data are reviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.