ArticleAmerican journal of nephrology2010
Chronic nitric oxide deficiency and progression of kidney disease after renal mass reduction in the C57Bl6 mouse.
Article in American journal of nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Vascular Function and Uric Acid-Lowering in Stage 3 CKD.Journal of the American Society of Nephrology : JASN · 2017Trial
- Randomized Trial of Dietary Nitrate Supplementation in CKD Pregnancy (ORCHARD-BEET).Kidney international reports · 2026Article
- Olive Leaf Extract Added to Losartan Treatment Improved Klotho/Wnt/β-Catenin Signaling in Hypertensive Rats with Focal Segmental Glomerulosclerosis.Antioxidants (Basel, Switzerland) · 2026Article
- The Hidden Burden of Gastroparesis in Chronic Kidney Disease: Evidence from Inpatient and Outpatient Cohorts for Personalized Care.Journal of personalized medicine · 2025Article
- Chronic kidney disease enhances alternative pathway activity: a new paradigm.The Journal of clinical investigation · 2025Review
- The NOS/NO System in Renal Programming and Reprogramming.Antioxidants (Basel, Switzerland) · 2023Review
- Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in Communities Study (CIRCS).Journal of atherosclerosis and thrombosis · 2021Article
- Reduced Renal Methylarginine Metabolism Protects against Progressive Kidney Damage.Journal of the American Society of Nephrology : JASN · 2015Article
- Activation of nuclear factor erythroid 2-related factor 2 coordinates dimethylarginine dimethylaminohydrolase/PPAR-γ/endothelial nitric oxide synthase pathways that enhance nitric oxide generation in human glomerular endothelial cells.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Assessment of vascular function in patients with chronic kidney disease.Journal of visualized experiments : JoVE · 2014Article
- Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass.American journal of physiology. Renal physiology · 2012Article
- Developmental programming of hypertension and kidney disease.International journal of nephrology · 2012Article
- Nitric oxide synthase derangements and hypertension in kidney disease.Current opinion in nephrology and hypertension · 2012Review
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
BACKGROUND/
aimsthe C57Bl6 mouse is resistant to chronic kidney disease (CKD) induced by reduction of renal mass (RRM). Nitric oxide (NO) deficiency exacerbates CKD progression so this study investigated whether combination of RRM and NO deficiency would render the C57Bl6 mouse vulnerable to CKD.
methodswe used wild-type (WT) mice with RRM, chronic NO synthase (NOS) inhibition and a combination. Also, endothelial NOS (eNOS) knockout (KO) C57Bl6 mice were studied with and without RRM. Primary endpoints were albuminuria and structural damage.
resultsboth nonselective (+L-NAME) and neuronal NOS 'selective' (+7NI) NOS inhibition greatly exacerbated the albuminuria and structural damage seen with RRM in the WT mice; NOS inhibition alone had little effect. The eNOS KO mice showed marked structural damage and significant albuminuria in the shams and RRM produced minimal exacerbation of structural damage although the albuminuria was massively amplified.
conclusionthese studies demonstrate that the C57Bl6 mouse is rendered vulnerable to RRM-induced CKD when concomitant NO deficiency is produced. This observation supports previous work in CKD-resistant rats and suggests that NO deficiency is required for progression of CKD.
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