ArticleThe Journal of biological chemistry2011
Evidence that prestin has at least two voltage-dependent steps.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Hearing Loss and Audiogenic Seizures Induced by Hypofunctional Prestin Variants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- SLC26 Anion Transporters.Handbook of experimental pharmacology · 2024Review
- Elevator-like movements of prestin mediate outer hair cell electromotility.Nature communications · 2023Article
- Prestin's fast motor kinetics is essential for mammalian cochlear amplification.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility.Nature communications · 2022Article
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- Kinetic Membrane Model of Outer Hair Cells.Biophysical journal · 2021Article
- A novel theoretical framework reveals more than one voltage-sensing pathway in the lateral membrane of outer hair cells.The Journal of general physiology · 2020Article
- The susceptibility of cochlear outer hair cells to cyclodextrin is not related to their electromotile activity.Acta neuropathologica communications · 2018Article
- The extracellular loop of pendrin and prestin modulates their voltage-sensing property.The Journal of biological chemistry · 2018Article
- Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice.Neural plasticity · 2018Article
- Diflunisal inhibits prestin by chloride-dependent mechanism.PloS one · 2017Article
- The R130S mutation significantly affects the function of prestin, the outer hair cell motor protein.Journal of molecular medicine (Berlin, Germany) · 2016Article
- The chloride-channel blocker 9-anthracenecarboxylic acid reduces the nonlinear capacitance of prestin-associated charge movement.The European journal of neuroscience · 2016Article
- Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent.Scientific reports · 2016Article
- Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats.Neural plasticity · 2016Article
- The Effects of Urethane on Rat Outer Hair Cells.Neural plasticity · 2016Article
- Active amplification in insect ears: mechanics, models and molecules.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Multiple discrete transitions underlie voltage-dependent activation in CLC Cl(-)/H(+) antiporters.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Prestin is a voltage-dependent membrane-spanning motor protein that confers electromotility on mammalian cochlear outer hair cells, which is essential for normal hearing of mammals. Voltage-induced charge movement in the prestin molecule is converted into mechanical work; however, little is known about the molecular mechanism of this process. For understanding the electromechanical coupling mechanism of prestin, we simultaneously measured voltage-dependent charge movement and electromotility under conditions in which the magnitudes of both charge movement and electromotility are gradually manipulated by the prestin inhibitor, salicylate. We show that the observed relationships of the charge movement and the physical displacement (q-d relations) are well represented by a three-state Boltzmann model but not by a two-state model or its previously proposed variant. Here, we suggest a molecular mechanism of prestin with at least two voltage-dependent conformational transition steps having distinct electromechanical coupling efficiencies.
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