ArticleScience (New York, N.Y.)2010
Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.
Article in Science (New York, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01584076 (Recovery From Amblyopia With Cholinesterase Inhibitors), which is not on this map. Cited by 223 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Recovery From Amblyopia With Cholinesterase Inhibitors
Who cites it
223 citing papers in PubMed, 3 syntheses or guidelines pooled it, 365 citations in OpenAlex.
- How perceptual learning rewires brain connectivity: lessons from the visual system in a top-down perspective.Frontiers in neural circuits · 2025Pooled it
- Critical period plasticity-related transcriptional aberrations in schizophrenia and bipolar disorder.Schizophrenia research · 2019Pooled it
- The challenges of amblyopia treatment.Biomedical journal · 2015Pooled it
- Durable recovery from amblyopia with donepezil.Scientific reports · 2023Trial
- Pronounced Neuroplasticity in the Primary Visual Cortex of the 13-Lined Ground Squirrel during Hibernation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Visual experience drives functional reorganization of cortical GABAergic circuits.bioRxiv : the preprint server for biology · 2026Article
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The balance between stability and plasticity of the visual word form area in dyslexia.Nature communications · 2025Article
- Temporary retinal inactivation reverses effects of long-term monocular deprivation in visual cortex by induction of burst mode firing in the thalamus.Cell reports · 2025Article
- Nicotinic Modulation of Fast-Spiking Neurons in Rat Somatosensory Cortex across Development.eNeuro · 2025Article
- Representational drift gates critical-period plasticity in mouse visual cortex.Current biology : CB · 2025Article
- Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis.Cell reports · 2025Article
- Ocular Dominance Plasticity: A Mini-Review.Eye and brain · 2025Review
- Abnormal response to chronic social defeat stress and fear extinction in a mouse model ofFrontiers in neuroscience · 2025Article
- Neonatal hypoxia-ischemia alters the events governing the hippocampal critical period of postnatal synaptic plasticity leading to deficits in working memory in mice.Neurobiology of disease · 2024Article
- Integration across biophysical scales identifies molecular and cellular correlates of person-to-person variability in human brain connectivity.Nature neuroscience · 2024Article
- Local and long-range input balance: A framework for investigating frontal cognitive circuit maturation in health and disease.Science advances · 2024Review
- Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development.Nature communications · 2024Article
- Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST.iScience · 2024Article
- Neural activity responsiveness by maturation of inhibition underlying critical period plasticity.Frontiers in neural circuits · 2024Article
163 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Experience-dependent brain plasticity typically declines after an early critical period during which circuits are established. Loss of plasticity with closure of the critical period limits improvement of function in adulthood, but the mechanisms that change the brain's plasticity remain poorly understood. Here, we identified an increase in expression of Lynx1 protein in mice that prevented plasticity in the primary visual cortex late in life. Removal of this molecular brake enhanced nicotinic acetylcholine receptor signaling. Lynx1 expression thus maintains stability of mature cortical networks in the presence of cholinergic innervation. The results suggest that modulating the balance between excitatory and inhibitory circuits reactivates visual plasticity and may present a therapeutic target.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.