Trial reportHaematologica2011
Prognostic factors for intensive care unit admission, intensive care outcome, and post-intensive care survival in patients with de novo acute myeloid leukemia: a single center experience.
Trial report in Haematologica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 154 citations in OpenAlex.
- Long-term health related quality of life following intensive care during treatment for haematological malignancies.PloS one · 2014Trial
- Incidence, etiology, and predictors of early mortality after induction chemotherapy for aml in a middle-income country.International journal of hematology · 2026Article
- Clinical and sociodemographic predictors of intensive care unit admission following chemotherapy in acute myeloid leukemia.Haematologica · 2026Article
- Immune interplay between sepsis and haematological malignancies.Intensive care medicine experimental · 2026Review
- Article
- Dynamic changes in mortality risk factors for acute leukemia patients in the ICU and Post-ICU periods.Annals of hematology · 2026Article
- Acute respiratory distress syndrome in patients with cancer: the YELENNA prospective multinational observational cohort study.Intensive care medicine · 2025Observational
- Outcomes of Elderly Patients Admitted to the Intensive Care Unit for Newly Diagnosed Acute Myeloid Leukemia.European journal of haematology · 2025Article
- Patients admitted in the intensive care unit after solid organ or bone marrow transplantation: Retrospective cohort study.World journal of transplantation · 2025Article
- Critically ill adult patients with acute leukemia: a systematic review and meta-analysis.Annals of intensive care · 2025Article
- The impact of renal dysfunction after critical illness on the management of cancer.Frontiers in nephrology · 2025Article
- The critical role of timely medical emergency team activation in oncological and non-oncological patients.PloS one · 2025Article
- Outcomes of intracranial hemorrhage in critically ill patients with acute leukemia: Results of a retrospective cohort study.Journal of intensive medicine · 2024Article
- Impact of critical illness on continuation of anticancer treatment and prognosis of patients with aggressive hematological malignancies.Annals of intensive care · 2024Article
- Sepsis mortality among patients with haematological malignancy admitted to intensive care 2000-2022: a binational cohort study.Critical care (London, England) · 2024Article
- Long-term survival and functional outcomes of critically ill patients with hematologic malignancies: a Canadian multicenter prospective study.Intensive care medicine · 2024Observational
- Can We Predict Acute Respiratory Distress Syndrome in Hematopoietic Stem Cell Recipients?American journal of respiratory and critical care medicine · 2024Article
- Outcome of critically ill patients receiving systemic chemotherapy on the intensive care unit.Frontiers in oncology · 2024Article
- Characteristics and outcomes of patients with acute myeloid leukemia admitted to intensive care unit with acute respiratory failure: a post-hoc analysis of a prospective multicenter study.Annals of intensive care · 2023Article
- Outcome of patients with newly diagnosed AML admitted to the ICU, including preemptive admission - a multi-center study.Annals of hematology · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute myeloid leukemia is a life-threatening disease associated with high mortality rates. A substantial number of patients require intensive care. This investigation analyzes risk factors predicting admission to the intensive care unit in patients with acute myeloid leukemia eligible for induction chemotherapy, the outcome of these patients, and prognostic factors predicting their survival. DESIGN AND
methodsA total of 406 consecutive patients with de novo acute myeloid leukemia (15-89 years) were analyzed retrospectively. Markers recorded at the time of diagnosis included karyotype, fibrinogen, C-reactive protein, and Charlson comorbidity index. In patients requiring critical care, the value of the Simplified Acute Physiology Score II, the need for mechanical ventilation, and vasopressor support were recorded at the time of intensive care unit admission. The independent prognostic relevance of the parameters was tested by multivariate analysis.
resultsSixty-two patients (15.3%) required intensive care, primarily due to respiratory failure (50.0%) or life-threatening bleeding (22.6%). Independent risk factors predicting intensive care unit admission were lower fibrinogen concentration, the presence of an infection, and comorbidity. The survival rate was 45%, with the Simplified Acute Physiology Score II being the only independent prognostic parameter (P<0.05). Survival was inferior in intensive care patients compared to patients not admitted to an intensive care unit. However, no difference between intensive care and non-intensive care patients was found concerning continuous complete remission at 6 years or survival at 6 years in patients who survived the first 30 days after diagnosis (non-intensive care patients: 28%; intensive care patients: 20%, P>0.05).
conclusionsOngoing infections, low fibrinogen and comorbidity are predictive for intensive care unit admission in acute myeloid leukemia. Although admission was a risk factor for survival, continuous complete remission and survival of patients alive at day 30 were similar in patients who were admitted or not admitted to an intensive care unit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.