ReviewCurrent opinion in chemical biology2010
Protein-polymer conjugates: synthetic approaches by controlled radical polymerizations and interesting applications.
Review in Current opinion in chemical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Biomolecule-polymer conjugates synthesized by a combination of organometallic bioconjugation and atom transfer radical polymerization.Polymer chemistry · 2026Article
- pH Controlled Activation and Stabilization of Enzymes Using Responsive Polymer-Bioconjugates.Biomacromolecules · 2025Article
- Photosystem I Photopolymerizes Pyrrole into Spherical Nanocomposites.Biomacromolecules · 2025Article
- Hydrogels from Protein-Polymer Conjugates: A Pathway to Next-Generation Biomaterials.Gels (Basel, Switzerland) · 2025Review
- Enzyme-Polymer Conjugates with Photocleavable Linkers for Control Over Protein Activity.Polymer chemistry · 2024Article
- Generating Ice-Binding Protein-Polymer Bioconjugates.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Carbon-Centered Radicals in Protein Manipulation.ACS central science · 2023Review
- Full-Atomistic Optimized Potentials for Liquid Simulations and Polymer Consistent Force Field Models for Biocompatible Shape-Memory Poly(ε-caprolactone).The journal of physical chemistry. B · 2022Article
- A comprehensive analysis in one run - in-depth conformation studies of protein-polymer chimeras by asymmetrical flow field-flow fractionation.Chemical science · 2021Article
- Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly.Polymers · 2021Review
- Protein-Based Nanohydrogels for Bioactive Delivery.Frontiers in chemistry · 2021Review
- Endophytic Nanotechnology: An Approach to Study Scope and Potential Applications.Frontiers in chemistry · 2021Review
- Nanohybrids as Protein-Polymer Conjugate Multimodal Therapeutics.Frontiers in medical technology · 2021Review
- Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer-Based Protein Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Transforming protein-polymer conjugate purification by tuning protein solubility.Nature communications · 2019Article
- Homodimeric Protein-Polymer Conjugates via the Tetrazine-Macromolecules · 2016Article
- One-component nanomedicine.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Degradable PEGylated Protein Conjugates Utilizing RAFT Polymerization.European polymer journal · 2015Article
- Smart hybrid materials by conjugation of responsive polymers to biomacromolecules.Nature materials · 2015Review
- Glyco-modification of protein withJournal of carbohydrate chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Protein-polymer conjugates are of interest to researchers in diverse fields. Attachment of polymers to proteins results in improved pharmacokinetics, which is important in medicine. From an engineering standpoint, conjugates are exciting because they exhibit properties of both the biomolecules and synthetic polymers. This allows the activity of the protein to be altered or tuned, anchoring to surfaces, and supramolecular self-assembly. Thus, there is broad interest in straightforward synthetic methods to prepare protein-polymer conjugates. Controlled radical polymerization (CRP) techniques have emerged as excellent strategies to make conjugates because the resulting polymers have narrow molecular weight distributions, targeted molecular weights, and attach to specific sites on proteins. Herein, recent advances in the synthesis and application of protein-polymer conjugates by CRP are highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.