ArticleFree radical biology & medicine2011
Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stress.
Article in Free radical biology & medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders.Journal of thrombosis and haemostasis : JTH · 2022Review
- Potential Therapeutic Benefits of Dipyridamole in COVID-19 Patients.Current pharmaceutical design · 2021Article
- Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus.The Journal of international medical research · 2020Article
- Effect of Diallyl Trisulfide on Ischemic Tissue Injury and Revascularization in a Diabetic Mouse Model.Journal of cardiovascular pharmacology · 2018Article
- Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis.EMBO molecular medicine · 2017Article
- Role of thiosulfate in hydrogen sulfide-dependent redox signaling in endothelial cells.American journal of physiology. Heart and circulatory physiology · 2017Article
- Bilirubin exerts pro-angiogenic property through Akt-eNOS-dependent pathway.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Article
- Nitrite anion therapy protects against chronic ischemic tissue injury in db/db diabetic mice in a NO/VEGF-dependent manner.Diabetes · 2014Article
- The neuron-astrocyte-microglia triad in a rat model of chronic cerebral hypoperfusion: protective effect of dipyridamole.Frontiers in aging neuroscience · 2014Article
- Control of angiogenesis dictated by picomolar superoxide levels.Free radical biology & medicine · 2013Article
- Cell therapy of peripheral arterial disease: from experimental findings to clinical trials.Circulation research · 2013Review
- Hydrogen sulfide stimulates ischemic vascular remodeling through nitric oxide synthase and nitrite reduction activity regulating hypoxia-inducible factor-1α and vascular endothelial growth factor-dependent angiogenesis.Journal of the American Heart Association · 2012Article
- High-throughput screening for bioactive molecules using primary cell culture of transgenic zebrafish embryos.Cell reports · 2012Article
- Emerging role of PKA/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseases.Cardiovascular research · 2012Review
- Proton-coupled electron-transfer mechanism for the radical scavenging activity of cardiovascular drug dipyridamole.PloS one · 2012Article
- Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing.International journal of vascular medicine · 2012Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Dipyridamole anti-platelet therapy has previously been suggested to ameliorate chronic tissue ischemia in healthy animals. However, it is not known if dipyridamole therapy represents a viable approach to alleviating chronic peripheral tissue ischemia associated with type 2 diabetes. Here we examine the hypothesis that dipyridamole treatment restores reperfusion of chronic hind-limb ischemia in the murine B6.BKS-Lepr(db/db) diabetic model. Dipyridamole therapy quickly rectified ischemic hind-limb blood flow to near preligation levels within 3 days of the start of therapy. Restoration of ischemic tissue blood flow was associated with increased vascular density and endothelial cell proliferation observed only in ischemic limbs. Dipyridamole significantly increased total nitric oxide metabolite levels in tissue, which were not associated with changes in endothelial NO synthase expression or phosphorylation. Interestingly, dipyridamole therapy significantly decreased ischemic tissue superoxide and protein carbonyl levels, identifying a dominant antioxidant mechanistic response. Dipyridamole therapy also moderately reduced diabetic hyperglycemia and attenuated development of dyslipidemia over time. Together, these data reveal that dipyridamole therapy is an effective modality for the treatment of chronic tissue ischemia during diabetes and highlights the importance of dipyridamole antioxidant activity in restoring tissue NO bioavailability during diabetes.
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