ArticleGastroenterology2011
Rescue of lethal hepatic failure by hepatized lymph nodes in mice.
Article in Gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 78 citations in OpenAlex.
- Bioprinted platform for parallelized screening of engineered microtissues in vivo.Cell stem cell · 2025Article
- 3D Printing of a Vascularized Mini-Liver Based on the Size-Dependent Functional Enhancements of Cell Spheroids for Rescue of Liver Failure.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Human Hepatocyte Transplantation: Three Decades of Clinical Experience and Future Perspective.Stem cells translational medicine · 2024Review
- Future medicine: from molecular pathways to the collective intelligence of the body.Trends in molecular medicine · 2023Review
- Cell therapy in end-stage liver disease: replace and remodel.Stem cell research & therapy · 2023Review
- Cellular Therapies in Pediatric Liver Diseases.Cells · 2022Review
- Fat-associated lymphoid clusters as expandable niches for ectopic liver development.Hepatology (Baltimore, Md.) · 2022Article
- Functional kupffer cells migrate to the liver from the intraperitoneal cavity.Biochemistry and biophysics reports · 2021Article
- Liver and Hepatocyte Transplantation: What Can Pigs Contribute?Frontiers in immunology · 2021Review
- Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2020Article
- Article
- Novel alternative transplantation therapy for orthotopic liver transplantation in liver failure: A systematic review.World journal of transplantation · 2020Article
- In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease.Science translational medicine · 2017Article
- Transplantation of hepatocytes from genetically engineered pigs into baboons.Xenotransplantation · 2017Article
- Emerging advancements in liver regeneration and organogenesis as tools for liver replacement.Current opinion in organ transplantation · 2016Review
- Regenerating a kidney in a lymph node.Pediatric nephrology (Berlin, Germany) · 2016Review
- Towards Organs on Demand: Breakthroughs and Challenges in Models of Organogenesis.Current pathobiology reports · 2016Article
- Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1.Science translational medicine · 2016Article
- Liver-Regenerative Transplantation: Regrow and Reset.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016Review
- Transplantation of human adipose stem cell-derived hepatocyte-like cells with restricted localization to liver using acellular amniotic membrane.Stem cell research & therapy · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsHepatocyte transplantation is a potential therapeutic approach for liver disease. However, most patients with chronic hepatic damage have cirrhosis and fibrosis, which limit the potential for cell-based therapy of the liver. The development of an ectopic liver as an additional site of hepatic function represents a new approach for patients with end-stage liver disease. We investigated the development and function of liver tissue in lymph nodes in mice with liver failure.
methodsHepatocytes were isolated from 8- to 12-week-old mice and transplanted by intraperitoneal injection into 8- to 12-week-old fumarylacetoacetate hydrolase mice (Fah(-/-)), a model of the human liver disease tyrosinemia type I. Survival was monitored and the locations and functions of the engrafted liver cells were determined.
resultsLymph nodes of Fah(-/-) mice were colonized by transplanted hepatocytes; Fah(+) hepatocytes were detected adjacent to the CD45(+) lymphoid cells of the lymphatic system. Ten weeks after transplantation, these mice had substantial improvements in serum levels of transaminases, bilirubin, and amino acids. Homeostatic expansion of donor hepatocytes in lymph nodes rescued the mice from lethal hepatic failure.
conclusionsFunctional ectopic liver tissue in lymph nodes rescues mice from lethal hepatic disease; lymph nodes therefore might be used as sites for hepatocyte transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.