ArticleGastroenterology2011
Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals.
Article in Gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 6 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Contribution of prostate stem cell antigen variation rs2294008 to the risk of bladder cancer.Medicine · 2019Pooled it
- PSCA rs2294008 Polymorphism with Increased Risk of Cancer.PloS one · 2015Pooled it
- Quantitative assessment of the influence of prostate stem cell antigen polymorphisms on gastric cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Functional polymorphism rs4072037 in MUC1 gene contributes to the susceptibility to gastric cancer: evidence from pooled 6,580 cases and 10,324 controls.Molecular biology reports · 2013Pooled it
- Survivin -31G>C polymorphism and gastrointestinal tract cancer risk: a meta-analysis.PloS one · 2013Pooled it
- The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis.Journal of cancer research and clinical oncology · 2012Pooled it
- Global, multicenter, randomized, phase II trial of gemcitabine and gemcitabine plus AGS-1C4D4 in patients with previously untreated, metastatic pancreatic cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Trial
- Significance of PSCA as a novel prognostic marker and therapeutic target for cancer.Cancer cell international · 2024Review
- SNP rs2920280 inDiagnostics (Basel, Switzerland) · 2022Article
- An association study on PSCA rs2294008 polymorphism and gastric cancer: A meta-analysis.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Article
- Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histology.Frontiers in public health · 2022Article
- LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5.EMBO reports · 2021Article
- Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer.Journal of epidemiology · 2021Article
- Polymorphism ofFrontiers in oncology · 2021Article
- A single nucleotide polymorphism inJournal of clinical biochemistry and nutrition · 2021Article
- Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.BMC medical genetics · 2020Article
- Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.Genes · 2020Article
- Impact ofBioscience reports · 2019Article
- Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level.Cancer medicine · 2018Article
- Decrease inOncotarget · 2018Article
Corrections and comments
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Authors and funding
19 authors at 11 institutions in 5 countries.
Funding
Abstract
BACKGROUND &
aimsAn association between gastric cancer and the rs2294008 (C>T) polymorphism in the prostate stem cell antigen (PSCA) gene has been reported for several Asian populations. We set out to determine whether such an association exists in white individuals.
methodsWe genotyped 166 relatives of gastric cancer patients, including 43 Helicobacter pylori-infected subjects with hypochlorhydria and gastric atrophy, 65 infected subjects without these abnormalities, 58 H pylori-negative relatives, and 100 population controls. Additionally, a population-based study of chronic atrophic gastritis provided 533 cases and 1054 controls. We then genotyped 2 population-based, case-control studies of upper gastrointestinal cancer: the first included 312 gastric cancer cases and 383 controls; the second included 309 gastric cancer cases, 159 esophageal cancer cases, and 211 controls. Odds ratios were computed from logistic models and adjusted for confounding variables.
resultsCarriage of the risk allele (T) of rs2294008 in PSCA was associated with chronic atrophic gastritis (adjusted odds ratio [OR], 1.5; 95% confidence interval [CI]: 1.1-1.9) and noncardia gastric cancer (OR, 1.9; 95% CI: 1.3-2.8). The association was strongest for the diffuse histologic type (OR, 3.2; 95% CI: 1.2-10.7). An inverse association was observed between carriage of the risk allele and gastric cardia cancer (OR, 0.5; 95% CI: 0.3-0.9), esophageal adenocarcinoma (OR, 0.5; 95% CI: 0.3-0.9), and esophageal squamous cell carcinoma (OR, 0.4; 95% CI: 0.2-0.9).
conclusionsThe rs2294008 polymorphism in PSCA increases the risk of noncardia gastric cancer and its precursors in white individuals but protects against proximal cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.