ArticleBMC genomics2010
Comparative genomics of prevaccination and modern Bordetella pertussis strains.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 93 citations in OpenAlex.
- Article
- Eosinophils as drivers of bacterial immunomodulation and persistence.Infection and immunity · 2024Review
- Genomic and transcriptomic variation in Bordetella spp. following induction of erythromycin resistance.The Journal of antimicrobial chemotherapy · 2022Article
- Evaluation of Outer Membrane Vesicles Obtained from Predominant Local Isolate of Boredetella pertussis as a Vaccine Candidate.Iranian biomedical journal · 2021Article
- Vaccine-Induced Cellular Immunity againstVaccines · 2021Review
- Review
- Comparative Phosphoproteomics of Classical Bordetellae Elucidates the Potential Role of Serine, Threonine and Tyrosine Phosphorylation inFrontiers in cellular and infection microbiology · 2021Article
- Comparison of Two Different Methods for the Extraction of Outer Membrane Vesicles from theArchives of Razi Institute · 2021Article
- Genome diversity and evolutionary characteristics of clinical isolates ofIranian journal of microbiology · 2020Article
- Development and Standardization of a High-ThroughputFrontiers in microbiology · 2020Article
- Article
- Activation of Human NK Cells byFrontiers in immunology · 2019Article
- Strain variation and antigenic divergence among Bordetella pertussis circulating strains isolated from patients in Iran.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models forFrontiers in immunology · 2018Review
- Comparison of the Whole Cell Proteome and Secretome of EpidemicFrontiers in microbiology · 2018Article
- Probing the Genome-Scale Metabolic Landscape of Bordetella pertussis, the Causative Agent of Whooping Cough.Applied and environmental microbiology · 2017Article
- Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface.PLoS pathogens · 2017Article
- The extent of the temperature-induced membrane remodeling in two closely relatedThe Journal of biological chemistry · 2017Article
- The relationship between mucosal immunity, nasopharyngeal carriage, asymptomatic transmission and the resurgence ofF1000Research · 2017Review
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite vaccination since the 1950s, pertussis has persisted and resurged. It remains a major cause of infant death worldwide and is the most prevalent vaccine-preventable disease in developed countries. The resurgence of pertussis has been associated with the expansion of Bordetella pertussis strains with a novel allele for the pertussis toxin (Ptx) promoter, ptxP3, which have replaced resident ptxP1 strains. Compared to ptxP1 strains, ptxP3 produce more Ptx resulting in increased virulence and immune suppression. To elucidate how B. pertussis has adapted to vaccination, we compared genome sequences of two ptxP3 strains with four strains isolated before and after the introduction vaccination.
resultsThe distribution of SNPs in regions involved in transcription and translation suggested that changes in gene regulation play an important role in adaptation. No evidence was found for acquisition of novel genes. Modern strains differed significantly from prevaccination strains, both phylogenetically and with respect to particular alleles. The ptxP3 strains were found to have diverged recently from modern ptxP1 strains. Differences between ptxP3 and modern ptxP1 strains included SNPs in a number of pathogenicity-associated genes. Further, both gene inactivation and reactivation was observed in ptxP3 strains relative to modern ptxP1 strains.
conclusionsOur work suggests that B. pertussis adapted by successive accumulation of SNPs and by gene (in)activation. In particular changes in gene regulation may have played a role in adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.