ArticleInternational journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity2011
Predicting cardiovascular risk in young adulthood from the metabolic syndrome, its component risk factors, and a cluster score in childhood.
Article in International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 106 citations in OpenAlex.
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- Effects of an Exercise Program on Cardiometabolic and Mental Health in Children With Overweight or Obesity: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2023Trial
- Confirmatory-factor-analysis-derived metabolic syndrome risk score: development, validation, and clinical utility in dual adolescent populations.Pediatric research · 2026Article
- Evaluating neonatal cord serum metabolome in association with adolescent cardiometabolic risk factors.Pediatric research · 2026Article
- Comprehensive cardiometabolic rehabilitation program for childhood obesity.Journal of health, population, and nutrition · 2026Article
- The Predictive Ability and Trend of Continuous Metabolic Syndrome (cMets) Score as a Marker for the Presence of Metabolic Syndrome among Iranian Adults from 2007 to 2025 Using STEPS Studies.International journal of preventive medicine · 2026Article
- Evaluating the association between longitudinal exposure to a PFAS mixture and adolescent cardiometabolic risk in the HOME Study.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Unsupervised identification of cardiometabolic profiles among adolescents: findings from the PARIS birth cohort study.European journal of pediatrics · 2024Article
- Cardiorespiratory fitness attenuates the association between fatness and cardiometabolic risk in Chinese children.Frontiers in endocrinology · 2024Article
- Late preterm birth and growth trajectories during childhood: a linked retrospective cohort study.BMC pediatrics · 2023Article
- The association between urinary cotinine level and metabolic syndrome profiles among adolescents: findings from the Ewha Birth and growth study.BMC public health · 2023Article
- Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity.Children (Basel, Switzerland) · 2023Review
- Is Metabolic Syndrome Useful for Identifying Youths with Obesity at Risk for NAFLD?Children (Basel, Switzerland) · 2023Article
- Enteropathy Markers in Early Life Were Associated with Adipokine, Apolipoprotein, and Cytokine Profiles Consistent with an Adverse Cardiometabolic Disease Risk Profile Later in Childhood in a Peruvian Birth Cohort.The American journal of tropical medicine and hygiene · 2022Article
- Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers.Annals of pediatric endocrinology & metabolism · 2021Article
- Does adjusting for biological maturity when calculating child weight status improve the accuracy of predicting future health risk?BMC public health · 2021Article
- Neonatal and Adolescent Adipocytokines as Predictors of Adiposity and Cardiometabolic Risk in Adolescence.Obesity (Silver Spring, Md.) · 2021Article
- Validity of continuous metabolic syndrome score for predicting metabolic syndrome; a systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2021Article
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- Gestational and childhood exposure to per- and polyfluoroalkyl substances and cardiometabolic risk at age 12 years.Environment international · 2021Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe value of metabolic syndrome (MetS) in childhood and adolescence and its stability into young adulthood have been questioned. This study compared the MetS in late childhood (mean age 13) versus a cluster score of the MetS components as predictors of young adult (mean age 22) cardiovascular risk.
methodsAnthropometrics, blood pressure, lipid profile, and insulin resistance (insulin clamp) were obtained in 265 individuals at mean ages 13 and 22. The MetS was defined dichotomously by current pediatric and adult criteria. The MetS cluster score used the average of deviates of the MetS components standardized to their means and standard deviations at mean age 13.
resultsThe MetS was rarely present at mean age 13 and did not predict MetS at mean age 22 but identified individuals who continued to have adverse levels of risk factors at mean age 22. In contrast to the standard MetS definition, the MetS cluster score tracked strongly and at mean age 22 was significantly higher in the individuals with MetS at mean age 13 (0.78 ± 0.71) than those without MetS at mean age 13 (0.09 ± 0.70, p <0.0001).
conclusionsAlthough the MetS at mean age 13, using the conventional definition, is not a reliable method for predicting the MetS at mean age 22, it does predict adverse levels of cardiovascular risk factors. A cluster score, using the MetS components as continuous variables, is more reliable in predicting young adult risk from late childhood.
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