ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Microarray identification of novel downstream targets of FoxD4L1/D5, a critical component of the neural ectodermal transcriptional network.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
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- Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.Genesis (New York, N.Y. : 2000) · 2016Article
- Early neural ectodermal genes are activated by Siamois and Twin during blastula stages.Genesis (New York, N.Y. : 2000) · 2015Article
- Retinoic acid signaling and neuronal differentiation.Cellular and molecular life sciences : CMLS · 2015Review
- Transcriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells.Journal of molecular neuroscience : MN · 2015Article
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- Neural transcription factors: from embryos to neural stem cells.Molecules and cells · 2014Review
- On becoming neural: what the embryo can tell us about differentiating neural stem cells.American journal of stem cells · 2013Article
- Conserved structural domains in FoxD4L1, a neural forkhead box transcription factor, are required to repress or activate target genes.PloS one · 2013Article
- Specific domains of FoxD4/5 activate and repress neural transcription factor genes to control the progression of immature neural ectoderm to differentiating neural plate.Developmental biology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
FoxD4L1/D5 is a forkhead transcription factor that functions as both a transcriptional activator and repressor. FoxD4L1/D5 acts upstream of several other neural transcription factors to maintain neural fate, regulate neural plate patterning, and delay the expression of neural differentiation factors. To identify a more complete list of downstream genes that participate in these earliest steps of neural ectodermal development, we carried out a microarray analysis comparing gene expression in control animal cap ectodermal explants (ACs), which will form epidermis, to that in FoxD4L1/D5-expressing ACs. Forty-four genes were tested for validation by RT-PCR of ACs and/or in situ hybridization assays in embryos; 86% of those genes up-regulated and 100% of those genes down-regulated in the microarray were altered accordingly in one of these independent assays. Eleven of these 44 genes are of unknown function, and we provide herein their developmental expression patterns to begin to reveal their roles in ectodermal development.
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