ArticleDevelopment genes and evolution2010
Developmental expression of COE across the Metazoa supports a conserved role in neuronal cell-type specification and mesodermal development.
Article in Development genes and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 49 citations in OpenAlex.
- The development of the adult nervous system in the annelid Owenia fusiformis.Neural development · 2024Article
- Activin/Nodal signaling mediates dorsal-ventral axis formation before third quartet formation in embryos of the annelidEvoDevo · 2020Article
- Molecular patterning during the development ofEvoDevo · 2019Article
- Integrating Embryonic Development and Evolutionary History to Characterize Tentacle-Specific Cell Types in a Ctenophore.Molecular biology and evolution · 2018Article
- The structure, splicing, synteny and expression of lamprey COE genes and the evolution of the COE gene family in chordates.Development genes and evolution · 2017Article
- A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis.Journal of visualized experiments : JoVE · 2016Article
- Article
- COE loss-of-function analysis reveals a genetic program underlying maintenance and regeneration of the nervous system in planarians.PLoS genetics · 2014Article
- Conserved MIP receptor-ligand pair regulates Platynereis larval settlement.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Global diversity of the Placozoa.PloS one · 2013Article
- Article
- Expression of collier in the premandibular segment of myriapods: support for the traditional Atelocerata concept or a case of convergence?BMC evolutionary biology · 2011Article
- Modularity of gene-regulatory networks revealed in sea-star development.BMC biology · 2011Article
- Coe genes are expressed in differentiating neurons in the central nervous system of protostomes.PloS one · 2011Article
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Authors and funding
11 authors at 7 institutions in 5 countries.
Funding
Abstract
The transcription factor COE (collier/olfactory-1/early B cell factor) is an unusual basic helix-loop-helix transcription factor as it lacks a basic domain and is maintained as a single copy gene in the genomes of all currently analysed non-vertebrate Metazoan genomes. Given the unique features of the COE gene, its proposed ancestral role in the specification of chemosensory neurons and the wealth of functional data from vertebrates and Drosophila, the evolutionary history of the COE gene can be readily investigated. We have examined the ways in which COE expression has diversified among the Metazoa by analysing its expression from representatives of four disparate invertebrate phyla: Ctenophora (Mnemiopsis leidyi); Mollusca (Haliotis asinina); Annelida (Capitella teleta and Chaetopterus) and Echinodermata (Strongylocentrotus purpuratus). In addition, we have studied COE function with knockdown experiments in S. purpuratus, which indicate that COE is likely to be involved in repressing serotonergic cell fate in the apical ganglion of dipleurula larvae. These analyses suggest that COE has played an important role in the evolution of ectodermally derived tissues (likely primarily nervous tissues) and mesodermally derived tissues. Our results provide a broad evolutionary foundation from which further studies aimed at the functional characterisation and evolution of COE can be investigated.
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