ArticleMetabolic brain disease2010
The influence of L-carnitine suplementation on the antioxidative abilities of serum and the central nervous system of ethanol-induced rats.
Article in Metabolic brain disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Therapeutic potential of L-carnitine in coronary artery disease: a systematic review.Inflammopharmacology · 2026Pooled it
- The effect of L-carnitine on inflammatory mediators: a systematic review and meta-analysis of randomized clinical trials.European journal of clinical pharmacology · 2019Pooled it
- Attenuation of DOX-Associated Biochemical and Histological Brain Alterations.Veterinary medicine and science · 2026Article
- Unraveling the nutritional challenges in epilepsy: Risks, deficiencies, and management strategies: A systematic review.World journal of experimental medicine · 2025Article
- Darbepoetin alpha has neuroprotective effects in the hippocampus against long-term intermittent ethanol administration.Experimental brain research · 2025Article
- Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine.Biology · 2021Article
- Carnitine in Alcohol Use Disorders: A Scoping Review.Alcoholism, clinical and experimental research · 2021Article
- L-Carnitine in Drosophila: A Review.Antioxidants (Basel, Switzerland) · 2020Review
- Anxiolytic and anti-stress effects of acute administration of acetyl-L-carnitine in zebrafish.PeerJ · 2018Article
- Lipids and Oxidative Stress Associated with Ethanol-Induced Neurological Damage.Oxidative medicine and cellular longevity · 2016Review
- L-carnitine reduces acute lung injury in experimental biliary obstruction.Saudi medical journal · 2015Article
- Identification of gene expression profile in the rat brain resulting from acute alcohol intoxication.Molecular biology reports · 2014Article
- Mechanisms underlying the anti-wasting effect of L-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies.European journal of nutrition · 2013Review
- Inhibition of gene expression of organic cation/carnitine transporter and antioxidant enzymes in oxazaphosphorines-induced acute cardiomyopathic rat models.Oxidative medicine and cellular longevity · 2012Article
- Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach.Free radical biology & medicine · 2011Article
- Doxorubicin toxicity can be ameliorated during antioxidant L-carnitine supplementation.Oxidative medicine and cellular longevityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain is exceptionally susceptible to oxidative stress that may be caused by xenobiotics such as ethanol. Alcohol metabolism is accompanied by enhanced free radical formation and a decrease in antioxidant abilities. However, L-carnitine appears to have antioxidant properties and the ability to regulate ethanol metabolism. The present study was designed to estimate the effect of L-carnitine on the antioxidant capacity of the rat brain and blood serum. For 5 weeks during the study, L-carnitine was given to rats in the amount of 1.5 g/1 l of drinking water, and from the second week the rats were intragastrically treated with ethanol. A significant decrease in the activity of antioxidant enzymes (Cu,Zn-SOD, GSH-Px, GSSG-R and CAT) and in the level of non-enzymatic antioxidants (vitamin C, E, A, GSH and GSH-t) as well as a significant increase in the level of GSSG in the brain and blood serum of ethanol intoxicated rats have been demonstrated. It has also been shown that alcohol caused a significant increase in the level of lipid peroxidation products-lipid hydroperoxides, malondialdehyde and 4-hydroxynonenal-and an increase in dityrosine, as well as a decrease in tryptophan-markers of protein oxidative modifications. The administration of L-carnitine to ethanol intoxicated rats partially normalized the activity of the examined enzymes and the level of the above non-enzymatic antioxidants. Moreover, L-carnitine significantly protects lipids and proteins against oxidative modifications. In conclusion, it has been proved that L-carnitine protects rat brain and blood serum against oxidative stress formation and it is possible that this small molecular amine has a similar beneficial effect on the human CNS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.