ArticleJournal of neural transmission (Vienna, Austria : 1996)2010
Pilot study: peripheral biomarkers for diagnosing sporadic Parkinson's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- Roles and therapeutic prospects of the laminin family in disorders of the nervous system.Journal of translational medicine · 2026Review
- Identification of Potential Biomarkers for Diagnosis of Patients with Methamphetamine Use Disorder.International journal of molecular sciences · 2023Article
- Upregulation of APAF1 and CSF1R in Peripheral Blood Mononuclear Cells of Parkinson's Disease.International journal of molecular sciences · 2023Article
- Article
- The rat rotenone model reproduces the abnormal pattern of central catecholamine metabolism found in Parkinson's disease.Disease models & mechanisms · 2022Article
- Preventive Vitamin A Supplementation Improves Striatal Function in 6-Hydroxydopamine Hemiparkinsonian Rats.Frontiers in nutrition · 2022Article
- ASL expression in ALDH1A1Human genetics · 2021Article
- Role and Mechanism of Vitamin A Metabolism in the Pathophysiology of Parkinson's Disease.Journal of Parkinson's disease · 2021Review
- Article
- Creation of a gene expression classifier for predicting Parkinson's disease rate of progression.Journal of neural transmission (Vienna, Austria : 1996) · 2020Observational
- rs3764435 Associated With Parkinson's Disease in Mexican Mestizos: Case-Control Study Reveals Protective Effects Against Disease Development and Cognitive Impairment.Frontiers in neurology · 2019Article
- Serum Amyloid Alpha Is Downregulated in Peripheral Tissues of Parkinson's Disease Patients.Frontiers in neuroscience · 2019Article
- Differential Alterations in Metabolism and Proteolysis-Related Proteins in Human Parkinson's Disease Substantia Nigra.Neurotoxicity research · 2018Article
- Pilot study: molecular risk factors for diagnosing sporadic Parkinson's disease based on gene expression in blood in MPTP-induced rhesus monkeys.Oncotarget · 2017Article
- Article
- Low Retinal Dehydrogenase 1 (RALDH1) Level in Prepubertal Boys with Autism Spectrum Disorder: A Possible Link to Dopamine Dysfunction?Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program.Biomarkers in medicine · 2017Article
- CSF Nrf2 and HSPA8 in Parkinson's disease patients with and without LRRK2 gene mutations.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Aldehyde dehydrogenase (ALDH) in Alzheimer's and Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Blood transcriptomics of drug-naïve sporadic Parkinson's disease patients.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The need for an early and differential diagnosis of Parkinson's disease (PD) is undoubtedly one of the main quests of the century. An early biomarker would enable therapy to begin sooner and would, hopefully, slow or better prevent progression of the disease. We performed transcript profiling via quantitative RT-PCR in RNA originating from peripheral blood samples. The groups were de novo (n = 11) and medicated PD (n = 94) subjects and healthy controls (n = 34), while for negative control Alzheimer's disease (AD; n = 14) subjects were recruited as an additional neurodegenerative disease. The results were retested on a second recruitment consisting 22 medicated PD subjects versus 33 controls and 12 AD. Twelve transcripts were chosen as candidate genes, according to previous postmortem brain profiling. Multiple analyses resulted in four significant genes: proteasome (prosome, macropain) subunit-alpha type-2 (PSMA2; p = 0.0002, OR = 1.15 95% CI 1.07-1.24), laminin, beta-2 (laminin S) (LAMB2; p = 0.0078, OR = 2.26 95% CI 1.24-4.14), aldehyde dehydrogenase 1 family-member A1 (ALDH1A1; p = 0.016, OR = 1.05 95% CI 1.01-1.1), and histone cluster-1 H3e (HIST1H3E; p = 0.03, OR = 0.975 95% CI 0.953-0.998) differentiating between medicated PD subjects versus controls. Using these four biomarkers for PD diagnosis, we achieved sensitivity and specificity of more than 80%. These biomarkers might be specific for PD diagnosis, since in AD subjects no significant results were observed. In the second validation, three genes (PSMA2, LAMB2 and ALDH1A1) demonstrated high reproducibility. This result supports previous studies of gene expression profiling and may facilitate the development of biomarkers for early diagnosis of PD.
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