ArticlePediatric nephrology (Berlin, Germany)2011
Serum cystatin C for estimation of residual renal function in children on peritoneal dialysis.
Article in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients.Renal failure · 2025Article
- Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children.Clinical pharmacokinetics · 2015Review
- C-terminal agrin fragment (CAF) as a serum biomarker for residual renal function in peritoneal dialysis patients.International urology and nephrology · 2015Observational
- Strategies for the preservation of residual renal function in pediatric dialysis patients.Pediatric nephrology (Berlin, Germany) · 2014Review
- Evaluation of the serum cystatin C values in prediction of indications for hemodialysis in patients with chronic renal failure.International urology and nephrology · 2014Article
- Residual renal function in children treated with chronic peritoneal dialysis.TheScientificWorldJournal · 2013Review
- Cystatin C in children on chronic hemodialysis.Pediatric nephrology (Berlin, Germany) · 2013Article
- Serum β-trace protein and risk of mortality in incident hemodialysis patients.Clinical journal of the American Society of Nephrology : CJASN · 2012Article
- Residual renal function assessment with cystatin C.Pediatric nephrology (Berlin, Germany) · 2011Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Residual renal function (RRF) is an important parameter in the management of patients on chronic dialysis. The aim of this cross-sectional study was to determine the efficacy of serum cystatin C (CysC) for RRF estimation in 20 children (16 boys, 4 girls; median age 13.4 years) undergoing peritoneal dialysis (PD). For studies of correlation with serum CysC, the average of creatinine clearance rate (Ccr) and urea clearance rate (Curea), Kt/Vurea, and weekly Ccr were evaluated as parameters reflecting RRF. The serum CysC level was found to be negatively correlated with urine volume (r=-0.717, P<0.001), average of Ccr and Curea (r=-0.851, P<0.001), total and renal weekly Ccr (r=-0.795, P<0.001; r=-0.845, P<0.001, respectively), and renal Kt/Vurea (r=-0.793, P<0.001) and positively correlated with peritoneal weekly Ccr (r=0.738, P<0.001) and peritoneal Kt/Vurea (r=0.785, P<0.001). There was no significant association with total Kt/Vurea (r=-0.335, P=0.148). In non-anuric group of patients, serum CysC had no link to peritoneal Kt/Vurea (r=0.573, P=0.066), but was negatively correlated with renal Kt/Vurea (r=-0.609, P=0.047). In the multiple regression analysis, renal Kt/Vurea significantly contributed to log CysC concentration rather than peritoneal Kt/Vurea. The results of this study suggest that serum CysC could be an appropriate marker for RRF, independent of total and peritoneal Kt/Vurea.
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