ArticleClinical research in cardiology : official journal of the German Cardiac Society2011
Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Use of BNP and NT-proBNP for the diagnosis of heart failure in the emergency department: a systematic review of the evidence.Heart failure reviews · 2014Pooled it
- TGF-β-Driven Atrial Fibrosis in Atrial Fibrillation: From Mechanistic Insights to Targeted Therapies.Aging and disease · 2025Review
- Molecular remodeling in comorbidities associated with heart failure: a current update.Molecular biology reports · 2024Review
- Number of Premature Ventricular Complexes Predicts Long-Term Outcomes in Patients with Persistent Atrial Fibrillation.Biomedicines · 2024Article
- The Role of Pro-Inflammatory Cytokines in the Pathogenesis of Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Macrophage Inflammatory Protein-1 Alpha, a Potential Biomarker for Predicting Left Atrial Remodeling in Patients With Atrial Fibrillation.Frontiers in cardiovascular medicine · 2021Article
- Atrial Fibrillation Is Associated with Increased Mortality in Patients Presenting with Ventricular Tachyarrhythmias.Scientific reports · 2019Article
- Metformin Inhibits the Expression of Biomarkers of Fibrosis of EPCs In Vitro.Stem cells international · 2019Article
- Atrial fibrillation in aging population.Aging medicine (Milton (N.S.W)) · 2018Review
- The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction.Scientific reports · 2017Article
- The multi-biomarker approach for heart failure in patients with hypertension.International journal of molecular sciences · 2015Article
- Fibrosis-related biomarkers and incident cardiovascular disease in older adults: the cardiovascular health study.Circulation. Arrhythmia and electrophysiology · 2014Article
- Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis.British journal of pharmacology · 2014Article
- Circulating fibrosis biomarkers and risk of atrial fibrillation: The Cardiovascular Health Study (CHS).American heart journal · 2014Article
- Connective tissue growth factor (CTGF/CCN2): diagnostic and prognostic value in acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Cardioembolic stroke diagnosis using blood biomarkers.Current cardiology reviews · 2013Review
- Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.Cardiovascular research · 2013Article
- Increased pericardial adipose tissue is correlated with atrial fibrillation and left atrial dilatation.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Quantification of active and total transforming growth factor-β levels in serum and solid organ tissues by bioassay.BMC research notes · 2012Article
- Procollagen propeptides: serum markers for atrial fibrosis?Clinical research in cardiology : official journal of the German Cardiac Society · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAtrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF.
methods401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation.
resultsMedian TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4-27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5-31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6-27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1-31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37-6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55-10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = -0.30, p = 0.007) and NT-proBNP (r = -0.14, p = 0.007).
conclusionsLow serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides.
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