ReviewMetallomics : integrated biometal science2010
Targeting selenium metabolism and selenoproteins: novel avenues for drug discovery.
Review in Metallomics : integrated biometal science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 41 citations in OpenAlex.
- Strategies for the Improvement of Metal-Based Chemotherapeutic Treatments.Biomedicines · 2021Review
- Article
- In Vitro Investigation of Auranofin as a Treatment for Clostridium difficile Infection.Drugs in R&D · 2020Article
- Inorganic Polysulfides and Related Reactive Sulfur–Selenium Species from the Perspective of Chemistry.Molecules (Basel, Switzerland) · 2019Review
- The Reactive Sulfur Species Concept: 15 Years On.Antioxidants (Basel, Switzerland) · 2017Review
- Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.Biological trace element research · 2016Article
- Insilico analysis of hypothetical proteins unveils putative metabolic pathways and essential genes in Leishmania donovani.Frontiers in genetics · 2014Article
- Exposure to silver nanoparticles inhibits selenoprotein synthesis and the activity of thioredoxin reductase.Environmental health perspectives · 2012Article
- Article
- Trace element levels in patients with familial mediterranean Fever.The Eurasian journal of medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Selenoproteins play a wide range of roles in metabolism and oxidative stress defense and are produced by organisms in all three domains of life. Recent evidence has been presented that metal based cancer drugs target the selenol nucleophile of the active site selenocysteine in thioredoxin reductase isoenzymes. Other metals and metalloids, such as tin, arsenic and gold, have also recently been shown to form stable complexes with hydrogen selenide, a required precursor for the synthesis of selenoproteins in all biological organisms. Moreover these metal based compounds have been shown to inhibit growth of pathogens such as Clostridium difficile and Treponema denticola due to their reactivity with this highly reactive metabolic precursor. This review summarizes the recent finding on these two avenues for drug discovery, and puts this work in context with the larger field of selenium biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.