ArticleNature2010
ON and OFF pathways in Drosophila motion vision.
Article in Nature, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers.
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Who cites it
169 citing papers in PubMed, 353 citations in OpenAlex.
- Cellular and functional dissection of the octopaminergic and tyraminergic system in the Drosophila brain.Current biology : CB · 2026Article
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- Synaptic high-frequency jumping synchronises vision to high-speed behaviour.Nature communications · 2026Article
- Homotypic dendritic interactions constrain growth and receptor distribution in Drosophila T4 neurons without affecting orientation or function.Development (Cambridge, England) · 2026Article
- Bio-Inspired Feedback Visual Network for Robust Small-Target Motion Detection in Complex Environments.Biomimetics (Basel, Switzerland) · 2026Article
- Making neural networks more neural.Patterns (New York, N.Y.) · 2026Article
- Differential temporal filtering in the fly optic lobe.Journal of computational neuroscience · 2025Article
- Serotonin selectively modulates visual responses of object motion detectors inJournal of neurophysiology · 2025Article
- Serotonin selectively modulates visual responses of object motion detectors inbioRxiv : the preprint server for biology · 2025Article
- Neurogenomic and behavioral principles shape freezing dynamics and synergistic performance in Drosophila melanogaster.Nature communications · 2025Article
- Visual threat avoidance while host seeking by Aedes aegypti mosquitoes.Cell reports · 2025Article
- Molecular mechanism establishing the OFF pathway in vision.Nature communications · 2025Article
- A recurrent neural circuit in Drosophila temporally sharpens visual inputs.Current biology : CB · 2025Article
- A Bio-Inspired Visual Neural Model for Robustly and Steadily Detecting Motion Directions of Translating Objects Against Variable Contrast in the Figure-Ground and Noise Interference.Biomimetics (Basel, Switzerland) · 2025Article
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- Article
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- A recurrent neural circuit inbioRxiv : the preprint server for biology · 2024Article
- Different spectral sensitivities of ON- and OFF-motion pathways enhance the detection of approaching color objects in Drosophila.Nature communications · 2023Article
- Neural mechanisms to incorporate visual counterevidence in self-movement estimation.Current biology : CB · 2023Article
109 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motion vision is a major function of all visual systems, yet the underlying neural mechanisms and circuits are still elusive. In the lamina, the first optic neuropile of Drosophila melanogaster, photoreceptor signals split into five parallel pathways, L1-L5. Here we examine how these pathways contribute to visual motion detection by combining genetic block and reconstitution of neural activity in different lamina cell types with whole-cell recordings from downstream motion-sensitive neurons. We find reduced responses to moving gratings if L1 or L2 is blocked; however, reconstitution of photoreceptor input to only L1 or L2 results in wild-type responses. Thus, the first experiment indicates the necessity of both pathways, whereas the second indicates sufficiency of each single pathway. This contradiction can be explained by electrical coupling between L1 and L2, allowing for activation of both pathways even when only one of them receives photoreceptor input. A fundamental difference between the L1 pathway and the L2 pathway is uncovered when blocking L1 or L2 output while presenting moving edges of positive (ON) or negative (OFF) contrast polarity: blocking L1 eliminates the response to moving ON edges, whereas blocking L2 eliminates the response to moving OFF edges. Thus, similar to the segregation of photoreceptor signals in ON and OFF bipolar cell pathways in the vertebrate retina, photoreceptor signals segregate into ON-L1 and OFF-L2 channels in the lamina of Drosophila.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.