ArticleNature2010
The environment and schizophrenia.
Article in Nature, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 593 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
593 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Global lifetime prevalence of schizophrenia: A systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Trauma-focused psychological interventions for psychosis: Meta-analytic evidence of differential effects on delusions and hallucinations.Psychological medicine · 2026Pooled it
- Identification of 1q25.2 as a novel shared locus between schizophrenia and major depressive disorder in east Asians by integrative analyses.Translational psychiatry · 2025Pooled it
- Inflammation in first-episode psychosis: The contribution of inflammatory biomarkers to the emergence of negative symptoms, a systematic review and meta-analysis.Acta psychiatrica Scandinavica · 2022Pooled it
- Plasma Orexin-A Levels in Patients With Schizophrenia: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2022Pooled it
- Traumatic Events, Social Adversity and Discrimination as Risk Factors for Psychosis - An Umbrella Review.Frontiers in psychiatry · 2021Pooled it
- Assessing Usage and Usability of a Narrative-Based Psychoeducational Digital Intervention to Improve Medication Adherence Among Individuals With Schizophrenia in a Stable Phase: Mixed Methods Study.Journal of medical Internet research · 2026Trial
- Prefrontal cortex stimulation prevents stress-induced HPA axis reactivity in people at familial risk of schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2025Trial
- Efficacy of a transdiagnostic, prevention-focused program for at-risk young adults: a waitlist-controlled trial.Psychological medicine · 2023Trial
- Lower multisensory temporal acuity in individuals with high schizotypal traits: a web-based study.Scientific reports · 2022Trial
- A hierarchical multi-scale framework for schizophrenia: integrating symptom networks, functional circuits, and molecular pathways.Molecular psychiatry · 2026Article
- Differential associations of childhood trauma subtypes with clinical symptoms, cognitive function, suicidal intent, and age at onset in Chinese patients with chronic schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Investigating changes in the blood-brain barrier in schizophrenia spectrum disorders: design and methodology of a longitudinal dynamic contrast-enhanced MRI study.European archives of psychiatry and clinical neuroscience · 2026Article
- Interrelationships of childhood trauma, psychiatric symptoms, neurocognition, and insomnia in chronic schizophrenia: a network perspective.European archives of psychiatry and clinical neuroscience · 2026Article
- Schizophrenia: from mechanism to therapy.Science China. Life sciences · 2026Review
- Protective Effects of Gallic Acid on Oxidative and Inflammatory Markers in the Hippocampus and Prefrontal Cortex of a Ketamine-Induced Schizophrenia-like Model.Brain sciences · 2026Article
- Biomarkers for Predicting Clinical Deterioration in Schizophrenia-Spectrum Disorders: A Systematic Review.Brain sciences · 2026Review
- Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance.bioRxiv : the preprint server for biology · 2026Article
- Environmental risk score as a predictor for 25-year symptom and functional trajectories in first episode psychosis.medRxiv : the preprint server for health sciences · 2026Article
- Are You Really Paranoid, Just Because They Are After You? Exploring the Underlying Sensitization Processes of Intersectional Discrimination on Everyday-Life Paranoia.Clinical psychology in Europe · 2026Article
533 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychotic syndromes can be understood as disorders of adaptation to social context. Although heritability is often emphasized, onset is associated with environmental factors such as early life adversity, growing up in an urban environment, minority group position and cannabis use, suggesting that exposure may have an impact on the developing 'social' brain during sensitive periods. Therefore heritability, as an index of genetic influence, may be of limited explanatory power unless viewed in the context of interaction with social effects. Longitudinal research is needed to uncover gene-environment interplay that determines how expression of vulnerability in the general population may give rise to more severe psychopathology.
Indexed as
Identifiers
21068828What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.