ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Cutting edge: Intrinsic programming of thymic γδT cells for specific peripheral tissue localization.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span.Science immunology · 2024Article
- Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles.Methods in molecular biology (Clifton, N.J.) · 2023Article
- IgG from Adult Atopic Dermatitis (AD) Patients Induces Nonatopic Neonatal Thymic Gamma-Delta T Cells (γδT) to Acquire IL-22/IL-17 Secretion Profile with Skin-Homing Properties and Epigenetic Implications Mediated by miRNA.International journal of molecular sciences · 2022Article
- γδ T Cells in Emerging Viral Infection: An Overview.Viruses · 2022Review
- Lymphoid tissue residency: A key to understand Tcf-1Frontiers in immunology · 2022Review
- Cell Adhesion Molecules in Normal Skin and Melanoma.Biomolecules · 2021Review
- Preferential Perinatal Development of Skin-Homing NK1.1iScience · 2020Article
- Role of Dendritic Epidermal T Cells in Cutaneous Carcinoma.Frontiers in immunology · 2020Review
- Regulation of γδ T Cell Effector Diversification in the Thymus.Frontiers in immunology · 2020Review
- Persistent gamma delta T-cell dysfunction in chronic HCV infection despite direct-acting antiviral therapy induced cure.Journal of viral hepatitis · 2019Article
- Toll-like receptors in immunity and inflammatory diseases: Past, present, and future.International immunopharmacology · 2018Review
- Functions of Vγ4 T Cells and Dendritic Epidermal T Cells on Skin Wound Healing.Frontiers in immunology · 2018Review
- A Task Force Against Local Inflammation and Cancer: Lymphocyte Trafficking to and Within the Skin.Frontiers in immunology · 2018Review
- Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells.Frontiers in immunology · 2018Review
- γδ T cells in homeostasis and host defence of epithelial barrier tissues.Nature reviews. Immunology · 2017Review
- TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets.Nature immunology · 2016Article
- T-Cell Therapy: Options for Infectious Diseases.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Review
- The role of chemokines in cutaneous immunosurveillance.Immunology and cell biology · 2015Review
- Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation.Nature communications · 2014Article
- Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness.Nature immunology · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skin-homing potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissue-specific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.