ArticleThe Journal of nutrition2011
α-Retinol is distributed through serum retinol-binding protein-independent mechanisms in the lactating sow-nursing piglet dyad.
Article in The Journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Metabolism of Neonatal Vitamin A Supplementation: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Systematic Review and Meta-Analysis of the Relative Dose-Response Tests to Assess Vitamin A Status.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Modified relative dose response values differ between lactating women in the United States and Indonesia.Experimental biology and medicine (Maywood, N.J.) · 2020Trial
- Vitamin A Requirements in Pregnancy and Lactation.Current developments in nutrition · 2020Review
- Dynamics of vitamin A uptake, storage, and utilization in vocal fold mucosa.Molecular metabolism · 2020Article
- Retinol isotope dilution accurately predicts liver reserves in piglets but overestimates reserves in lactating sows.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Total Adipose Retinol Concentrations Are Correlated with Total Liver Retinol Concentrations in Male Mongolian Gerbils, but Only Partially Explained by Chylomicron Deposition Assessed with Total α-Retinol.Current developments in nutrition · 2019Article
- Relative contribution of α-carotene to postprandial vitamin A concentrations in healthy humans after carrot consumption.The American journal of clinical nutrition · 2017Article
- Single High-Dose Vitamin A Supplementation to Neonatal Piglets Results in a Transient Dose Response in Extrahepatic Organs and Sustained Increases in Liver Stores.The Journal of nutrition · 2017Article
- Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models.Advances in nutrition (Bethesda, Md.) · 2017Review
- Biomarkers of Nutrition for Development (BOND)-Vitamin A Review.The Journal of nutrition · 2016Review
- An HPLC-MS/MS method for the separation of α-retinyl esters from retinyl esters.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2016Article
- Healthy birth weight results in higher vitamin A storage in neonate piglets administered high-dose supplements.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- α-Retinol and 3,4-didehydroretinol support growth in rats when fed at equimolar amounts and α-retinol is not toxic after repeated administration of large doses.The British journal of nutrition · 2014Article
- 3, 4-Didehydroretinol kinetics differ during lactation in sows on a retinol depletion regimen and the serum:milk 3, 4-didehydroretinol:retinol ratios are correlated.The Journal of nutrition · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
α-Retinol (αR) is a structural isomer of retinol [vitamin A (VA)] that does not bind to serum retinol-binding protein (RBP). In this study, α-retinyl acetate (αRA) was synthesized and given orally (35 μmol) to VA-deficient lactating sows (n = 11) to assess its potential to trace RBP-independent retinol transport and tissue uptake. The αRA dose primarily appeared in sow serum as 4 α-retinyl esters (αRE) with peak serum total αR concentrations (the sum of the alcohol and ester forms) detected at 2 h (70 ± 23 nmol/L, mean ± SEM) postdose. From 0 to 40 h postdose, the percentage of serum total αR in the alcohol form did not increase. Rapid αR uptake into sow milk was observed with peak concentrations (371 ± 83 nmol/L) at 7.5 h postdose, consistent with the uptake of αRE from chylomicra. A high percentage of the αRA dose (62 ± 15%, mean ± SD) was present in the livers of sows (n = 6) killed 22-28 d postdose. Approximately 15-26% of the sow αRA dose was transferred to the livers of the nursing piglets (n = 17) after 3 d. In piglets and sows, a similar percentage of hepatic total αR was detected in the ester form as that of hepatic total retinol. Taken together, these data suggest that an oral dose of αRA effectively traces the uptake, esterification, chylomicron transport, and hepatic storage of retinol and may be useful for deciphering the role of RBP-independent delivery of retinol to other tissues.
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