ArticleBMC medical genetics2010
SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in African-Americans of the GENOA study.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
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- Metabolites Associated With Risk of Developing Mobility Disability in the Health, Aging and Body Composition Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Metabolic profiling of adherence to diet, physical activity and body size recommendations for cancer prevention.Scientific reports · 2018Article
- Metabolites related to renal function, immune activation, and carbamylation are associated with muscle composition in older adults.Experimental gerontology · 2017Article
- Metabolites Associated With Circulating Interleukin-6 in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Whole exome analyses to examine the impact of rare variants on left ventricular traits in African American participants from the HyperGEN and GENOA studies.Journal of hypertension and management · 2017Article
- High order gene-gene interactions in eight single nucleotide polymorphisms of renin-angiotensin system genes for hypertension association study.BioMed research international · 2015Article
- Article
- Particle swarm optimization algorithm for analyzing SNP-SNP interaction of renin-angiotensin system genes against hypertension.Molecular biology reports · 2013Article
- The utility of copy number variation (CNV) in studies of hypertension-related left ventricular hypertrophy (LVH): rationale, potential and challenges.Molecular cytogenetics · 2013Article
- Serum glycine is associated with regional body fat and insulin resistance in functionally-limited older adults.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular mass (LVM) is a strong, independent predictor of heart disease incidence and mortality. LVM is a complex, quantitative trait with genetic and environmental risk factors. This research characterizes the genetic architecture of LVM in an African-American population by examining the main and interactive effects of individual candidate gene single nucleotide polymorphisms (SNPs) and conventional risk factors for increased LVM.
methodsWe used least-squares linear regression to investigate 1,878 SNPs from 234 candidate genes for SNP main effects, SNP-risk factor interactions, or SNP-SNP interactions associated with LVM in 1,328 African-Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. We reduced the probability of false positive results by implementing three analytic criteria: 1) the false discovery rate, 2) cross-validation, and 3) testing for internal replication of results.
resultsWe identified 409 SNP-SNP interactions passing all three criteria, while no SNP main effects or SNP-risk factor interactions passed all three. A multivariable model including four SNP-SNP interactions explained 11.3% of the variation in LVM in the full GENOA sample and 5.6% of LVM variation in independent test sets.
conclusionsThe results of this research underscore that context dependent effects, specifically SNP-SNP interactions, may dominate genetic contributions to variation in complex traits such as LVM.
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