ArticleVirology journal2010
A novel totivirus and piscine reovirus (PRV) in Atlantic salmon (Salmo salar) with cardiomyopathy syndrome (CMS).
Article in Virology journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55 citing papers in PubMed, 155 citations in OpenAlex.
- Vaccination Reduces Shedding of Salmonid Alphavirus Subtype 3, but Bacterial Co-Infection Influences the Effect.Journal of fish diseases · 2026Article
- Integrated approaches for pathogen monitoring and shotgun metagenomic analysis in Atlantic salmon farming.Scientific reports · 2026Article
- Discovery of a novel orthototivirus-like virus in patients with vulvovaginal candidiasis.Frontiers in cellular and infection microbiology · 2026Article
- Beating Cardiac Cell Cultures From Different Developmental Stages of Rainbow Trout as a Novel Approach for Replication of Cardiac Fish Viruses.Journal of fish diseases · 2025Article
- Genomic analysis reveals low genetic diversity and no continuous reintroduction of piscine myocarditis virus in farmed Atlantic salmon in the Faroe Islands.The Journal of general virology · 2025Article
- PRV-1b and PRV-3a infection is associated with the same clinical disease in coho salmon (Oncorhynchus kisutch) farmed in Chile: unraveling the pathogenesis of the orthoreoviral cardiomyopathy and hemolytic jaundice (OCHJ).Veterinary research · 2025Article
- Evaluating Atlantic Salmon (Pathogens (Basel, Switzerland) · 2024Article
- A novel high-throughput qPCR chip for solving co-infections in RAS farmed rainbow trout.Scientific reports · 2024Article
- Diversity, evolution, and emergence of fish viruses.Journal of virology · 2024Review
- Detection, sequencing, and tissue distribution of piscine orthoreovirus 2-like virus in diseased coho salmon in Alaska.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Metagenomic of Liver Tissue Identified at Least Two Genera of Totivirus-like Viruses inMicroorganisms · 2024Article
- An Atypical Course of Cardiomyopathy Syndrome (CMS) in Farmed Atlantic Salmon (Microorganisms · 2023Article
- Characterization of a New Toti-like Virus in Sea Bass,Viruses · 2023Article
- Long-term persistence of piscine orthoreovirus-1 (PRV-1) infection during the pre-smolt stages of Atlantic salmon in freshwater.Veterinary research · 2023Article
- Characterization of early phases of cardiomyopathy syndrome pathogenesis in Atlantic salmon (Salmo salar L.) through various diagnostic methods.Journal of fish diseases · 2022Article
- Elimination of LRVs Elicits Different Responses inmSphere · 2022Article
- Structures of L-BC virus and its open particle provide insight into Totivirus capsid assembly.Communications biology · 2022Article
- Analyses ofViruses · 2021Article
- Discovery and surveillance of viruses from salmon in British Columbia using viral immune-response biomarkers, metatranscriptomics, and high-throughput RT-PCR.Virus evolution · 2021Article
- Virome composition in marine fish revealed by meta-transcriptomics.Virus evolution · 2021Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiomyopathy syndrome (CMS) is a severe disease affecting large farmed Atlantic salmon. Mortality often appears without prior clinical signs, typically shortly prior to slaughter. We recently reported the finding and the complete genomic sequence of a novel piscine reovirus (PRV), which is associated with another cardiac disease in Atlantic salmon; heart and skeletal muscle inflammation (HSMI). In the present work we have studied whether PRV or other infectious agents may be involved in the etiology of CMS.
resultsUsing high throughput sequencing on heart samples from natural outbreaks of CMS and from fish experimentally challenged with material from fish diagnosed with CMS a high number of sequence reads identical to the PRV genome were identified. In addition, a sequence contig from a novel totivirus could also be constructed. Using RT-qPCR, levels of PRV in tissue samples were quantified and the totivirus was detected in all samples tested from CMS fish but not in controls. In situ hybridization supported this pattern indicating a possible association between CMS and the novel piscine totivirus.
conclusionsAlthough causality for CMS in Atlantic salmon could not be proven for either of the two viruses, our results are compatible with a hypothesis where, in the experimental challenge studied, PRV behaves as an opportunist whereas the totivirus might be more directly linked with the development of CMS.
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