ArticleBMC evolutionary biology2010
Origin and evolution of a placental-specific microRNA family in the human genome.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
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- Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases.International journal of molecular sciences · 2022Review
- Hsa-miR-422a Originated from Short Interspersed Nuclear Element IncreasesMolecules and cells · 2022Article
- Abnormal Circulating Maternal miRNA Expression Is Associated with a Low (<4%) Cell-Free DNA Fetal Fraction.Diagnostics (Basel, Switzerland) · 2021Article
- Genetic Polymorphisms inInternational journal of molecular sciences · 2021Article
- Role of Transposable Elements in Gene Regulation in the Human Genome.Life (Basel, Switzerland) · 2021Review
- Exosomes as Messengers Between Mother and Fetus in Pregnancy.International journal of molecular sciences · 2020Review
- Association Between miR-605A>G, miR-608G>C, miR-631I>D, miR-938C>T, and miR-1302-3C>T Polymorphisms and Risk of Recurrent Implantation Failure.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases.International journal of endocrinology · 2018Review
- Placental Exosomes During Gestation: Liquid Biopsies Carrying Signals for the Regulation of Human Parturition.Current pharmaceutical design · 2018Review
- DROSHA targets its own transcript to modulate alternative splicing.RNA (New York, N.Y.) · 2017Article
- Identification and Expression of Equine MER-Derived miRNAs.Molecules and cells · 2017Article
- Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream.International journal of molecular sciences · 2017Article
- Conserved expression of transposon-derived non-coding transcripts in primate stem cells.BMC genomics · 2017Article
- Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications.Journal of pregnancy · 2017Review
- The role of Alu elements in the cis-regulation of RNA processing.Cellular and molecular life sciences : CMLS · 2015Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNAs) are a class of short regulatory RNAs encoded in the genome of DNA viruses, some single cell organisms, plants and animals. With the rapid development of technology, more and more miRNAs are being discovered. However, the origin and evolution of most miRNAs remain obscure. Here we report the origin and evolution dynamics of a human miRNA family.
resultsWe have shown that all members of the miR-1302 family are derived from MER53 elements. Although the conservation scores of the MER53-derived pre-miRNA sequences are low, we have identified 36 potential paralogs of MER53-derived miR-1302 genes in the human genome and 58 potential orthologs of the human miR-1302 family in placental mammals. We suggest that in placental species, this miRNA family has evolved following the birth-and-death model of evolution. Three possible mechanisms that can mediate miRNA duplication in evolutionary history have been proposed: the transposition of the MER53 element, segmental duplications and Alu-mediated recombination. Finally, we have found that the target genes of miR-1302 are over-represented in transportation, localization, and system development processes and in the positive regulation of cellular processes. Many of them are predicted to function in binding and transcription regulation.
conclusionsThe members of miR-1302 family that are derived from MER53 elements are placental-specific miRNAs. They emerged at the early stage of the recent 180 million years since eutherian mammals diverged from marsupials. Under the birth-and-death model, the miR-1302 genes have experienced a complex expansion with some members evolving by segmental duplications and some by Alu-mediated recombination events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.