ArticleImmunome research2010
State of the art and challenges in sequence based T-cell epitope prediction.
Article in Immunome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- DeepHLApan: A Deep Learning Approach for the Prediction of Peptide-HLA Binding and Immunogenicity.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A state-of-the-art methodology for high-throughput in silico vaccine discovery against protozoan parasites and exemplified with discovered candidates for Toxoplasma gondii.Scientific reports · 2023Article
- Review on Approved and Inprogress COVID-19 Vaccines.Iranian journal of pharmaceutical research : IJPR · 2022Review
- SILVI, an open-source pipeline for T-cell epitope selection.PloS one · 2022Article
- Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances.International journal of nanomedicine · 2022Review
- epitopepredict: a tool for integrated MHC binding prediction.GigaByte (Hong Kong, China) · 2021Article
- Revealing factors determining immunodominant responses against dominant epitopes.Immunogenetics · 2020Review
- INeo-Epp: A Novel T-Cell HLA Class-I Immunogenicity or Neoantigenic Epitope Prediction Method Based on Sequence-Related Amino Acid Features.BioMed research international · 2020Article
- Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms.Cancers · 2019Review
- Update on Tumor Neoantigens and Their Utility: Why It Is Good to Be Different.Trends in immunology · 2018Review
- Bioinformatics analysis of single and multi-hybrid epitopes of GRA-1, GRA-4, GRA-6 and GRA-7 proteins to improve DNA vaccine design againstJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- Systems Immunology: Learning the Rules of the Immune System.Annual review of immunology · 2018Review
- Development of a strategy and computational application to select candidate protein analogues with reduced HLA binding and immunogenicity.Immunology · 2018Article
- Deep convolutional neural networks for pan-specific peptide-MHC class I binding prediction.BMC bioinformatics · 2017Article
- Short peptide epitope design from hantaviruses causing HFRS.Bioinformation · 2017Article
- Integrated computational prediction and experimental validation identifies promiscuous T cell epitopes in the proteome ofMicrobial genomics · 2016Article
- TepiTool: A Pipeline for Computational Prediction of T Cell Epitope Candidates.Current protocols in immunology · 2016Article
- A combined approach of human leukocyte antigen ligandomics and immunogenicity analysis to improve peptide-based cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2015Review
- Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens.Journal of immunology research · 2015Review
- HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequence based T-cell epitope predictions have improved immensely in the last decade. From predictions of peptide binding to major histocompatibility complex molecules with moderate accuracy, limited allele coverage, and no good estimates of the other events in the antigen-processing pathway, the field has evolved significantly. Methods have now been developed that produce highly accurate binding predictions for many alleles and integrate both proteasomal cleavage and transport events. Moreover have so-called pan-specific methods been developed, which allow for prediction of peptide binding to MHC alleles characterized by limited or no peptide binding data. Most of the developed methods are publicly available, and have proven to be very useful as a shortcut in epitope discovery. Here, we will go through some of the history of sequence-based predictions of helper as well as cytotoxic T cell epitopes. We will focus on some of the most accurate methods and their basic background.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.