ReviewCritical care (London, England)2010
Bench-to-bedside review: hypercapnic acidosis in lung injury--from 'permissive' to 'therapeutic'.
Review in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Effects of hypercapnia versus normocapnia during general anesthesia on outcomes: a systematic review and meta-analysis.Brazilian journal of anesthesiology (Elsevier)Pooled it
- Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Oxygen, carbon dioxide, and nitric oxide: role in the pathophysiology of obstructive sleep apnea.Medical gas research · 2027Review
- The Acid-Base Effects of Albumin in Sepsis: Reconciling the Stewart Physicochemical Approach with the Traditional Buffer-Base Paradigm.Journal of clinical medicine · 2026Review
- Molecular and Cellular Signaling Pathways of the Effects of Hypoxia and Hypercapnia on the Mechanisms of Neuroinflammation.International journal of molecular sciences · 2026Review
- Evaluation of ventilation at 10 °C as the optimal storage condition for donor lungs in a murine model.Scientific reports · 2026Article
- Sensing molecular carbon dioxide: a translational focus for respiratory disease.Physiological reviews · 2025Review
- Low Tidal Volume Ventilation in Percutaneous Liver Ablations: Preliminary Experience on 10 Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Time-varying intensity of ventilatory inefficiency and mortality in patients with acute respiratory distress syndrome.Annals of intensive care · 2025Article
- Chloride Reduction Therapy with Furosemide: Short-Term Effects in Children with Acute Respiratory Failure.Journal of pediatric intensive care · 2023Article
- Addition of 5% COAmerican journal of respiratory and critical care medicine · 2021Article
- Acidic preconditioning reduces lipopolysaccharide-induced acute lung injury by upregulating the expression of angiotensin-converting enzyme 2.Experimental and therapeutic medicine · 2021Article
- Hypercapnia in the critically ill: insights from the bench to the bedside.Interface focus · 2021Review
- Bi-Level Positive Airway Pressure for Non-invasive Respiratory Support of Foals.Frontiers in veterinary science · 2021Article
- THAM reduces CO2-associated increase in pulmonary vascular resistance - an experimental study in lung-injured piglets.Critical care (London, England) · 2015Article
- Update on the role of extracorporeal CO₂ removal as an adjunct to mechanical ventilation in ARDS.Critical care (London, England) · 2015Review
- Extracorporeal support for patients with acute respiratory distress syndrome.European respiratory review : an official journal of the European Respiratory Society · 2014Review
- Permissive hypercapnia: Is there any upper limit?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014Article
- Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction.Critical care (London, England) · 2014Article
- Effects of clinically relevant acute hypercapnic and metabolic acidosis on the cardiovascular system: an experimental porcine study.Critical care (London, England) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern ventilation strategies for patients with acute lung injury and acute respiratory distress syndrome frequently result in hypercapnic acidosis (HCA), which is regarded as an acceptable side effect ('permissive hypercapnia'). Multiple experimental studies have demonstrated advantageous effects of HCA in several lung injury models. To date, however, human trials studying the effect of carbon dioxide per se on outcome in patients with lung injury have not been performed. While significant concerns regarding HCA remain, in particular the possible unfavorable effects on bacterial killing and the inhibition of pulmonary epithelial wound repair, the potential for HCA in attenuating lung injury is promising. The underlying mechanisms by which HCA exerts its protective effects are complex, but dampening of the inflammatory response seems to play a pivotal role. After briefly summarizing the physiological effects of HCA, a critical analysis of the available evidence on the potential beneficial effects of therapeutic HCA from in vitro, ex vivo and in vivo lung injury models and from human studies will be reviewed. In addition, the potential concerns in the clinical setting will be outlined.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.