ArticleThe Journal of infectious diseases2010
Dynamic coinfection with multiple viral subtypes in acute hepatitis C.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing.PLoS pathogens · 2012Trial
- Molecular characterization and evolutionary dynamics of a recombinant PDCoV strain in a swine diarrhea epidemic with SADS-CoV co-infection.Frontiers in veterinary science · 2026Article
- Castanet: a pipeline for rapid analysis of targeted multi-pathogen genomic data.Bioinformatics (Oxford, England) · 2024Article
- Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients.Genome medicine · 2021Article
- Infection with multiple hepatitis C virus genotypes detected using commercial tests should be confirmed using next generation sequencing.Scientific reports · 2019Article
- Transmission of hepatitis C virus in the dialysis setting and strategies for its prevention.Seminars in dialysis · 2019Review
- Hepatitis C in Laos: A 7-Year Retrospective Study on 1765 Patients.Virologica Sinica · 2018Article
- Characterization of Hepatitis C Virus (HCV) Envelope Diversification from Acute to Chronic Infection within a Sexually Transmitted HCV Cluster by Using Single-Molecule, Real-Time Sequencing.Journal of virology · 2017Article
- Comparison of Next-Generation Sequencing Technologies for Comprehensive Assessment of Full-Length Hepatitis C Viral Genomes.Journal of clinical microbiology · 2016Article
- Single-Genome Sequencing of Hepatitis C Virus in Donor-Recipient Pairs Distinguishes Modes and Models of Virus Transmission and Early Diversification.Journal of virology · 2016Article
- Review
- Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission.Nature communications · 2015Article
- Article
- Article
- Dynamics of HCV RNA levels during acute hepatitis C virus infection.Journal of medical virology · 2014Article
- Use of short tandem repeat fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies.The Journal of general virology · 2014Article
- Vertical transmission of hepatitis C virus: a tale of multiple outcomes.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- HAVCR1 gene haplotypes and infection by different viral hepatitis C virus genotypes.Clinical and vaccine immunology : CVI · 2012Article
- A new evolutionary model for hepatitis C virus chronic infection.PLoS pathogens · 2012Article
- The natural history of early hepatitis C virus evolution; lessons from a global outbreak in human immunodeficiency virus-1-infected individuals.The Journal of general virology · 2011Review
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Authors and funding
9 authors.
Funding
Abstract
introductionAcute hepatitis C virus (HCV) infection is rarely studied, but virus sequence evolution and host-virus dynamics during this early stage may influence the outcome of infection. Hypervariable region 1 (HVR1) is genetically diverse and under selective pressure from the host immune response. We analyzed HVR1 evolution by frequent sampling of an acutely infected HCV cohort.
methodsThree or more pretreatment samples were obtained from each of 10 acutely infected subjects. Polymerase chain reaction amplification was performed with multiple primer combinations to identify the full range of sequences present. Positive samples were cloned and sequenced. Phylogenetic analyses were used to assess viral diversity.
resultsEight of the 10 subjects were coinfected with at least 2 HCV subtypes. Multiple subtypes were detected in individual samples, and their relative proportions changed through acute infection. The subjects with the most complex subtype structure also had a dynamic viral load; however, changes in viral load were not directly linked to changes in subtype.
conclusionsThis well-sampled cohort with acute HCV infection was characterized by dynamic coinfection with multiple viral subtypes, representing a highly complex virologic landscape extremely early in infection.
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