ReviewWiley interdisciplinary reviews. Systems biology and medicine
Synthetic biology: putting synthesis into biology.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Design of bacterial DNT sensors based on computational models.Nucleic acids research · 2026Article
- Molecular Paleontology Meets Drug Discovery: The Case for De-extinct Antimicrobials.ACS omega · 2025Review
- Engineering Useful Microbial Species for Pharmaceutical Applications.Microorganisms · 2025Review
- Hashing the message with cells.Nature chemical biology · 2025Article
- Engineering natural microbiomes toward enhanced bioremediation by microbiome modeling.Nature communications · 2024Article
- Comprehensive Bio-Screening of Phytochemistry and Biological Capacity ofBiomolecules · 2024Article
- Towards AI-driven longevity research: An overview.Frontiers in aging · 2023Review
- Cloning short DNA into plasmids by one-step PCR.Thoracic cancer · 2020Article
- CRISPR-Cas9 Genome Editing Tool for the Production of Industrial Biopharmaceuticals.Molecular biotechnology · 2020Review
- Genetic tool development and systemic regulation in biosynthetic technology.Biotechnology for biofuels · 2018Review
- Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Chemical Society reviews · 2015Review
- Targeted delivery system of nanobiomaterials in anticancer therapy: from cells to clinics.BioMed research international · 2014Review
- New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris.Current opinion in biotechnology · 2013Review
- Challenges and opportunities in synthetic biology for chemical engineers.Chemical engineering science · 2013Article
- Directed evolution of bacteriorhodopsin for applications in bioelectronics.Journal of the Royal Society, Interface · 2013Article
- Directed evolution as a powerful synthetic biology tool.Methods (San Diego, Calif.) · 2013Article
- A computational pipeline for identifying kinetic motifs to aid in the design and improvement of synthetic gene circuits.BMC bioinformatics · 2013Article
- Directed evolution: an evolving and enabling synthetic biology tool.Current opinion in chemical biology · 2012Review
- Biocatalyst development by directed evolution.Bioresource technology · 2012Review
- OmniChange: the sequence independent method for simultaneous site-saturation of five codons.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The ability to manipulate living organisms is at the heart of a range of emerging technologies that serve to address important and current problems in environment, energy, and health. However, with all its complexity and interconnectivity, biology has for many years been recalcitrant to engineering manipulations. The recent advances in synthesis, analysis, and modeling methods have finally provided the tools necessary to manipulate living systems in meaningful ways and have led to the coining of a field named synthetic biology. The scope of synthetic biology is as complicated as life itself--encompassing many branches of science and across many scales of application. New DNA synthesis and assembly techniques have made routine customization of very large DNA molecules. This in turn has allowed the incorporation of multiple genes and pathways. By coupling these with techniques that allow for the modeling and design of protein functions, scientists have now gained the tools to create completely novel biological machineries. Even the ultimate biological machinery--a self-replicating organism--is being pursued at this moment. The aim of this article is to dissect and organize these various components of synthetic biology into a coherent picture.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.